Positive Regulation of Staphylococcal Enterotoxin H by Rot (Repressor of Toxin) Protein and Its Importance in Clonal Complex 81 Subtype 1 Lineage-Related Food Poisoning

Applied and Environmental Microbiology
Yusuke Sato'oMotoyuki Sugai

Abstract

We previously demonstrated the clonal complex 81 (CC81) subtype 1 lineage is the major staphylococcal food poisoning (SFP)-associated lineage in Japan (Y. Sato'o et al., J Clin Microbiol 52:2637-2640, 2014, http://dx.doi.org/10.1128/JCM.00661-14). Strains of this lineage produce staphylococcal enterotoxin H (SEH) in addition to SEA. However, an evaluation of the risk for the recently reported SEH has not been sufficiently conducted. We first searched for staphylococcal enterotoxin (SE) genes and SE proteins in milk samples that caused a large SFP outbreak in Japan. Only SEA and SEH were detected, while there were several SE genes detected in the samples. We next designed an experimental model using a meat product to assess the productivity of SEs and found that only SEA and SEH were detectably produced in situ. Therefore, we investigated the regulation of SEH production using a CC81 subtype 1 isolate. Through mutant analysis of global regulators, we found the repressor of toxin (Rot) functioned oppositely as a stimulator of SEH production. SEA production was not affected by Rot. seh mRNA expression correlated with rot both in media and on the meat product, and the Rot protein was shown to directly bind to the seh promoter. The ...Continue Reading

References

Jan 1, 1988·Methods in Enzymology·M S Bergdoll
Jun 5, 2002·Lancet·Tadashi BabaKeiichi Hiramatsu
Dec 24, 2002·Infection and Immunity·Dong-Liang HuKunihiro Shinagawa
Jan 4, 2003·Journal of Bacteriology·B Saïd-SalimB N Kreiswirth
Dec 1, 1963·Journal of Bacteriology·J I FREAF M STRONG
Jan 22, 2004·FEMS Immunology and Medical Microbiology·Ambrose L CheungYan-Qiong Xiong
Mar 5, 2004·Journal of Bacteriology·Ching Wen TsengGeorge C Stewart
May 5, 2005·Applied and Environmental Microbiology·Tetsuya IkedaSou-ichi Makino
Jul 21, 2005·Journal of Bacteriology·Ching Wen Tseng, George C Stewart
Aug 23, 2005·Infection and Immunity·Katsuhiko OmoeKunihiro Shinagawa
Oct 11, 2005·FEMS Microbiology Letters·Hannah J JørgensenSemir Loncarevic
Aug 2, 2006·Molecular Microbiology·Edward GeisingerRichard P Novick
Feb 20, 2007·International Journal of Food Microbiology·A KérouantonM L De Buyser
Dec 18, 2007·The International Journal of Biochemistry & Cell Biology·Ambrose L CheungSandeep Tamber
Jan 5, 2008·Infection and Immunity·Dongmei Li, Ambrose Cheung
Aug 20, 2008·Infection and Immunity·Hisaya K OnoKunihiro Shinagawa
Oct 20, 2009·Food Microbiology·Sylviane DerzelleVéronique Deperrois
Feb 2, 2011·Infection and Immunity·Fuminori KatoMotoyuki Sugai
Aug 2, 2011·Journal of Microbiological Methods·Fuminori Kato, Motoyuki Sugai
Nov 19, 2011·FEMS Microbiology Reviews·Jacques-Antoine HennekinneSylviane Dragacci
Jun 12, 2012·Journal of Bacteriology·Meredith A BensonVictor J Torres
Jul 17, 2012·Applied and Environmental Microbiology·Xiaomei YanHajo Grundmann
Dec 21, 2012·Microbiology and Immunology·Yusuke Sato'oDong-Liang Hu
Jul 24, 2013·Infection and Immunity·Katsuhiko OmoeKen'ichi Imanishi
Nov 5, 2013·European Journal of Pharmacology·Dong-Liang Hu, Akio Nakane
May 31, 2014·FEBS Letters·Pierre FechterPascale Romby
Jul 18, 2014·International Journal of Food Microbiology·A FetschB Strommenger

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Citations

Aug 29, 2016·Journal of Microbiological Methods·Junzo HisatsuneMotoyuki Sugai
Apr 1, 2017·Critical Reviews in Food Science and Nutrition·Noreddine Benkerroum
Jan 11, 2017·Foodborne Pathogens and Disease·Justyna SchubertJacek Bania
May 31, 2018·Pathogens·Stephen W TuffsJohn K McCormick
Apr 18, 2018·Frontiers in Microbiology·Emilie L FisherGordon Y C Cheung
Oct 6, 2020·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Naoto IshizakiYoshiko Sugita-Konishi
Aug 29, 2021·International Journal of Food Microbiology·Kaoru UmedaDong-Liang Hu

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