Positive relationship between p42.3 gene and inflammation in chronic non-atrophic gastritis

Journal of Digestive Diseases
Ping ChenXiao-Yu Chen

Abstract

Gastric cancer (GC) is a typical type of inflammation-related tumor. The p42.3 gene is shown to be highly expressed in GC, but its association with gastritis remains unknown. We aimed to explore the relationship between gastric inflammation and p42.3 gene in vitro and in vivo. Normal gastric epithelial cells (GES-1) were treated with Helicobacter pylori (H. pylori) and tumor necrosis factor (TNF)-α. Total cell mRNA and protein were extracted and collected, and polymerase chain reaction and Western blot were performed to determine the relative expression of p42.3 gene. In total, 291 biopsy samples from patients with chronic non-atrophic gastritis were collected and immunohistochemistry was used to measure the p42.3 protein expression. The association between p42.3 protein expression and the clinicopathological characteristics of these patients were analyzed. Both H. pylori and TNF-α significantly enhanced the p42.3 protein expression in GES-1 cells in a time and dose-dependent manner. In addition, p42.3 gene expression was positively associated with the severity of gastric mucosal inflammation and H. pylori infection (P = 0.000). Its expression was significantly more common in severe gastric inflammation and in H. pylori-infecte...Continue Reading

References

Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G R van Den BrinkM P Peppelenbosch
Oct 13, 2000·Gastroenterology Clinics of North America·J R Warren
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Victor J TorresTimothy L Cover
Oct 13, 2010·Infectious Disease Clinics of North America·M Blanca PiazueloPelayo Correa
Sep 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Prashant JainSteven R Blanke
Dec 23, 2011·Journal of Digestive Diseases·Pelayo Correa, M Blanca Piazuelo
Sep 11, 2012·Journal of Cellular Biochemistry·Acacia Lamb, Lin-Feng Chen
Sep 28, 2012·Methods in Molecular Biology·Jennifer M Noto, Richard M Peek
Nov 21, 2012·International Journal of Oncology·Vincenza ConteducaFranco Dammacco
Aug 29, 2013·Cancer Letters·Fei WangLiang Qiao
Sep 28, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming LiYahong Gu
Oct 26, 2013·Trends in Microbiology·Laura K Greenfield, Nicola L Jones
Mar 22, 2014·Seminars in Immunology·Guadalupe Sabio, Roger J Davis
Jul 22, 2014·Journal of Gastroenterology and Hepatology·Jung Mogg KimYoung-Jeon Kim
Sep 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Chih WangChiou-Feng Lin
Oct 21, 2014·Journal of Gastric Cancer·Jung Hwan YoonWon Sang Park

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