Positive selection in ASPM is correlated with cerebral cortex evolution across primates but not with whole-brain size

Molecular Biology and Evolution
Farhan Ali, Rudolf Meier

Abstract

The rapid increase of brain size is a key event in human evolution. Abnormal spindle-like microcephaly associated (ASPM) is discussed as a major candidate gene for explaining the exceptionally large brain in humans but ASPM's role remains controversial. Here we use codon-specific models and a comparative approach to test this candidate gene that was initially identified in Homo-chimp comparisons. We demonstrate that accelerated evolution of ASPM (omega = 4.7) at 16 amino acid sites occurred in 9 primate lineages with major changes in relative cerebral cortex size. However, ASPM's evolution is not correlated with major changes in relative whole-brain or cerebellum sizes. Our results suggest that a single candidate gene such as ASPM can influence a specific component of the brain across large clades through changes in a few amino acid sites. We furthermore illustrate the power of using continuous phenotypic variability across primates to rigorously test candidate genes that have been implicated in the evolution of key human traits.

References

Jan 1, 1981·Folia primatologica; international journal of primatology·H StephanG Baron
Jun 16, 1995·Science·B L Finlay, R B Darlington
Jun 1, 1997·Journal of Human Evolution·R J Smith, W L Jungers
Nov 21, 1997·Computer Applications in the Biosciences : CABIOS·Z Yang
May 29, 2002·Molecular Biology and Evolution·Ziheng Yang, Rasmus Nielsen
Oct 2, 2002·Nature Genetics·Jacquelyn BondC Geoffrey Woods
Aug 13, 2003·Bioinformatics·Fredrik Ronquist, John P Huelsenbeck
Jan 15, 2004·Human Molecular Genetics·Patrick D EvansBruce T Lahn
Oct 29, 2004·Bioinformatics·Sergei L Kosakovsky PondSpencer V Muse
Apr 5, 2005·American Journal of Human Genetics·C Geoffrey WoodsWolfgang Enard
May 27, 2005·Current Opinion in Genetics & Development·Chris Ponting, Andrew P Jackson
Jun 24, 2005·Human Molecular Genetics·Natalay KouprinaVladimir Larionov
Jul 13, 2005·Trends in Genetics : TIG·Morris GoodmanDerek E Wildman
May 12, 2006·Human Molecular Genetics·Roger P WoodsJohn C Mazziotta
Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jennifer L FishWieland B Huttner
Sep 19, 2006·Trends in Genetics : TIG·Peng ShiJianzhi Zhang
Mar 7, 2007·Molecular Biology and Evolution·Maria Anisimova, Ziheng Yang
Feb 5, 2008·Genetics·Joanna L Kelley, Willie J Swanson

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Citations

Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Blythe A WilliamsE Christopher Kirk
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lars M RimolUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 22, 2010·Molecular Biology and Evolution·Stephen H MontgomeryNicholas I Mundy
Feb 24, 2010·BMC Genomics·Juan I Montoya-BurgosIlham Bahechar
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Oct 3, 2012·PloS One·Fernando A VillaneaNathaniel J Dominy
Jun 6, 2014·BMC Evolutionary Biology·Stephen H Montgomery, Nicholas I Mundy
Nov 14, 2013·Brain & Development·Akira FujimoriShinji Fushiki
Feb 18, 2011·Cellular and Molecular Life Sciences : CMLS·Nadine KraemerAngela M Kaindl
Nov 3, 2009·Gene·Gianluca TettamantiGiorgio Binelli
Nov 26, 2009·Progress in Neurobiology·Angela M KaindlPierre Gressens
Sep 2, 2009·Trends in Ecology & Evolution·Chris Venditti, Mark Pagel
Nov 11, 2010·Annals of the New York Academy of Sciences·Tracy J Dixon-Salazar, Joseph G Gleeson
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Edward C Gilmore, Christopher A Walsh
Jul 3, 2015·Frontiers in Neuroscience·Don M Gash, Andrew S Deane
Oct 24, 2009·Trends in Genetics : TIG·Gemma K Thornton, C Geoffrey Woods
May 24, 2019·Genes, Brain, and Behavior·Sheel V SinghBrenda J Bradley
May 28, 2020·Frontiers in Cellular Neuroscience·Elke GabrielJay Gopalakrishnan

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