PMID: 8941964Sep 1, 1996Paper

Positive selection of EqCD8+ precursors increases equine lymphokine-activated killing

Veterinary Immunology and Immunopathology
D P LunnO J Ginther

Abstract

Lymphokine activated killing (LAK) is an example of natural cytotoxicity, and as such is a critical means of defense against diseases such as viral infection and neoplasia. Despite this important role, the specific molecular interactions involved in LAK or other forms of natural cytotoxicity are only partially understood. In some species, cells capable of mediating natural cytotoxicity express the CD8 molecule, although no specific role has been demonstrated for CD8 in non-MHC restricted cytotoxicity. In this study the role of the EqCD8 equine homolog of CD8 in LAK cell activity was examined. A series of LAK assays were performed using equine lymphocyte populations enriched or depleted for EqCD8 expression by positive or negative selection. The results indicate that positive selection of LAK precursors using an anti-EqCD8 (CVS8) antibody greatly increases LAK cytotoxicity. The implications for the role of the EqCD8 molecules in LAK are discussed.

References

Apr 1, 1992·Veterinary Immunology and Immunopathology·C E HormanskiD W Horohov
Feb 15, 1990·International Journal of Cancer. Journal International Du Cancer·D K BlanchardJ Y Djeu
Oct 1, 1985·The Journal of Experimental Medicine·I Bank, L Chess
Oct 1, 1986·The Journal of Experimental Medicine·J R OrtaldoR Overton
Jan 1, 1993·Veterinary Immunology and Immunopathology·D P LunnW P Duffus
Sep 10, 2004·Current Molecular Medicine·M A Morris, K Ley

❮ Previous
Next ❯

Citations

Oct 8, 1999·Developmental and Comparative Immunology·M M Viveiros, D F Antczak
Nov 14, 1997·Journal of Reproductive Immunology·P LunnO J Ginther
Jun 25, 1998·Veterinary Immunology and Immunopathology·D P LunnK E Vagnoni
Jul 10, 1998·Veterinary Immunology and Immunopathology·M J FlaminioW Shuman
Sep 1, 1996·American Journal of Reproductive Immunology : AJRI·K E VagnoniD P Lunn
Sep 27, 2007·Bioscience, Biotechnology, and Biochemistry·Takashi MimitsukaKatsushige Yamada

❮ Previous
Next ❯

Related Concepts

Related Feeds