PMID: 8976173Dec 1, 1996Paper

Positive selection of gamma delta CTL by TL antigen expressed in the thymus

The Journal of Experimental Medicine
K TsujimuraY Obata

Abstract

To elucidate the funciton of the mouse TL antigen in the thymus, we have derived two TL transgenic mouse strains by introducing Tl alpha 2-3 of A strain origin with its own promoter onto a C3H background with no expression of TL in the thymus. These transgenic mouse strains, both of which express high levels of Tla2-3-TL antigen in their thymus, were analyzed for their T cell function with emphasis on cytotoxic T lymphocyte (CTL) generation. A T cell response against TL was induced in Tg. Tla2-3-1, Tg. Tla2-3-2, and control C3H mice by skin grafts from H-2Kb/T3b transgenic mice, Tg.Con.3-1, expressing T3b-TL ubiquitously. Spleen cells from mice that had rejected the T3b-TL positive skin grafts were restimulated in vitro with Tg. Con.3-1 irradiated spleen cells. In mixed lymphocyte cultures (MLC), approximately 20% and 15% of Thy-1+ T cells derived from Tg.Tla2-3-1 and Tg.Tla2-3-2, respectively, expressed TCR gamma delta, whereas almost all those from C3H expressed TCR alpha beta. The MLC from Tg. Tla2-3-2 and C3H demonstrated high CTL activity against TL, while those from Tg. Tla2-3-1 had little or none. The generation of gamma delta CTL recognizing TL in Tg. Tla2-3-2, but not C3H mice, was confirmed by the establishment of CTL...Continue Reading

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Citations

Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael LahnWilli K Born
Jul 3, 2016·Immunogenetics·Courtney K Anderson, Laurent Brossay
Mar 27, 2003·Nature Reviews. Immunology·Adrian Hayday, Robert Tigelaar
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dominique A WeberPeter E Jensen
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TsujimuraT Takahashi
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masaki TerabeJay A Berzofsky
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian DaviesMark J Soloski
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antoine AttingerPaula Kavathas

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