PMID: 6165994Jan 1, 1981Paper

Positive selection of major histocompatibility complex-restricted suppressor T cells bearing the predominant idiotype in the immune response to lysozyme

Proceedings of the National Academy of Sciences of the United States of America
B A AraneoE E Sercarz

Abstract

The lysozyme system provides an excellent model for studying the role of multiple major histocompatibility complex (MHC) genes in the induction and regulation of Ir-gene controlled immune responses. Immunization of H-2b mice leads to concomitant activation of helper and suppressor activities by different epitopes on hen egg-white lysozyme (HEL) and thus phenotype unresponsiveness to native HEL. HEL-specific suppressor T cells in C57BL/10 nonresponder mice show MHC restriction, because their enrichment on antigen-pulsed macrophage monolayers requires syngeneic macrophages as well as HEL. The expression of the selected suppressor function requires interaction between the restricted suppressor precursor cell and an HEL-triggered, suppressor-inducer T cell. The MHC-restricted suppressor precursors bear the predominant idiotype found on anti-HEL antibodies, whereas MHC-restricted helpers do not.

References

May 1, 1975·European Journal of Immunology·S W Hill, E E Sercarz
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D W Thomas, E M Shevach
Jan 1, 1978·Immunological Reviews·E E SercarzL Adorini
Mar 1, 1977·Somatic Cell Genetics·M L GefterM D Scharff
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J F MillerJ Gamble
Nov 2, 1976·The Journal of Experimental Medicine·S K Pierce, N R Klinman
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D H KatzB Benacerraf
Feb 1, 1972·Cellular Immunology·R E ClickB J Alter
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

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Citations

Aug 1, 1980·Springer Seminars in Immunopathology·E E Sercarz, D W Metzger
Apr 1, 1982·Immunology Today·E Simpson
Jan 1, 1983·Annals of the New York Academy of Sciences·E E SercarzR Yowell
Feb 7, 2008·Journal of Periodontology·Taichi ItoTetsuo Kato

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