Positive selection of the bat interferon alpha gene family.

Biochemical Genetics
Guimei HeJie Cui

Abstract

Type I interferons (IFNs) are produced by leukocytes in reaction to pathogenic infection and function as positive mediators in antiviral pathways. Among IFNs, IFN alpha (IFNA) has the largest number of family members and plays an important role against the invasion of pathogens. Bats are putative and proven vectors for numerous viruses; however, the evolution of the IFNA family in bats has not been addressed. Here, we construct a phylogeny of IFNA families, including one fruit bat (Dobsonia viridis), with other vertebrates as references. Site-model estimation reveals that positive selection has shaped bat IFNA genes, showing that positive selection drives the evolution of bat IFNA genes.

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Citations

Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peng ZhouMichelle L Baker
Feb 16, 2012·Antiviral Research·Osvaldo MartinezChristopher F Basler
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Jan 27, 2017·Journal of Virology·Ivan V KuzminAlexander Bukreyev
Jan 1, 2011·Emerging Health Threats Journal·Ivan V KuzminCharles E Rupprecht
May 23, 2019·Proceedings of the National Academy of Sciences of the United States of America·John A HawkinsSara L Sawyer

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Methods Mentioned

BETA
GTPases
biopsy
PCR

Software Mentioned

Mega
Clustal X
GeneConv
PAML4

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