PMID: 2505933Sep 22, 1989Paper

Positive selection of the T cell repertoire: where and when does it occur?

Cell
C Benoist, D Mathis

Abstract

The T cell repertoire is shaped by both positive and negative influences. T lymphocytes that express the V beta 6 variable region are positively selected in the thymus by cells expressing major histocompatibility complex (MHC) class II E molecules. To identify these cells, we have quantitated V beta 6+ T lymphocytes in a set of transgenic mice showing variant patterns of E expression in the thymus. We demonstrate that class II molecules must be expressed on epithelial cells of the cortex for positive selection to occur. Using a direct assay of unmanipulated thymocytes, we show that positive selection is manifest only as a rather late event in thymocyte differentiation, after the maturation of cortical double-positives into single-positives.

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 1, 1979·Immunological Reviews·J A Ledbetter, L A Herzenberg
Mar 2, 1989·Nature·J C Zuñiga-PfluckerA M Kruisbeek
Feb 1, 1989·Immunology Today·H von BoehmerP Kisielow
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H von BoehmerS Tonegawa
Aug 1, 1988·Immunological Reviews·H R MacDonaldD H Raulet
Dec 1, 1988·Nature·F Zepp, U D Staerz
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M McDuffieJ Kappler
Sep 24, 1987·Nature·I N CrispeR P Shimonkevitz
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A DornD Mathis
Sep 15, 1988·Nature·C A Janeway
Nov 24, 1988·Nature·H HengartnerR M Zinkernagel
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A BehlkeD Y Loh
Apr 24, 1987·Cell·J W KapplerP Marrack
Jan 1, 1986·Immunologic Research·D LoJ Sprent
Aug 28, 1987·Science·H OhkiN M Le Douarin
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D L LongoL A Matis

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Citations

Sep 1, 1992·Cancer Metastasis Reviews·N J McCarthyG T Williams
Jan 1, 1992·Immunogenetics·K Tomonari, S Fairchild
Feb 1, 1997·Immunologic Research·D LoL H Glimcher
Jan 28, 1994·Cell·H von Boehmer
Jul 1, 1995·Developmental and Comparative Immunology·T RiekerG Wick
May 1, 1990·Trends in Neurosciences·M R MontminyK K Yamamoto
Apr 1, 1990·Immunology Today·E V Rothenberg
Oct 1, 1990·Immunology Today·E Houssaint, M Flajnik
May 1, 1994·Immunology Today·T J Pawlowski, U D Staerz
Nov 1, 1993·International Journal of Immunopharmacology·M C LopezR R Watson
Apr 1, 1991·Current Opinion in Immunology·H von Boehmer
Feb 1, 1991·Current Opinion in Immunology·K M Murphy
Jun 11, 2005·Seminars in Immunology·Li Wu, Ken Shortman
Jan 17, 2002·Journal of Immunological Methods·D H D GrayR L Boyd
Aug 5, 2005·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Sandra S SandsRobert J Ketchum
May 28, 2011·Nature Reviews. Immunology·Jacques F A P Miller
Oct 16, 1999·The New England Journal of Medicine·M L MarkertB F Haynes
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y FukuiT Sasazuki
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P HugoP Marrack
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J S MarkowitzL H Glimcher
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·D AmsenA M Kruisbeek
Aug 1, 1990·The Journal of Experimental Medicine·J PenningerG Wick
Apr 1, 1992·The Journal of Experimental Medicine·T MartinT J Kipps
May 1, 1992·The Journal of Experimental Medicine·M H HermansD Opstelten
Jun 1, 1992·The Journal of Experimental Medicine·T MizuochiK Hirokawa
Aug 1, 1992·The Journal of Experimental Medicine·D CosgroveD Mathis
Sep 1, 1992·The Journal of Experimental Medicine·E J JenkinsonJ J Owen
Apr 1, 1993·The Journal of Experimental Medicine·F B WellsL A Matis
Mar 1, 1994·The Journal of Experimental Medicine·A O HueberH T He
Jun 1, 1994·The Journal of Experimental Medicine·G AndersonE J Jenkinson

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