Positive selection pressure on the B/C domains of the E2-gene of classical swine fever virus in endemic areas under C-strain vaccination

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Lester J PérezLlilianne Ganges

Abstract

In Cuba, classical swine fever (CSF) has become an endemic disease with several outbreaks each year, despite the implemented vaccination program. Interestingly, a trend towards a milder presentation of the disease has been observed among the animals during the last years. This study aimed to assess positive selection pressure acting on partial E2 gene of CSF viruses to gain insights into the mechanisms governing virulence and the driving forces of classical swine fever virus (CSFV) evolution in swine populations under regular vaccination. Selection pressure analysis were performed to detect positive selection acting on a particular lineage as well as among sites of the E2-B/C-domain of CSFV nucleotide sequences, reported in a previous study and in the present work, several models, available in the CODEML module of PAML 4.3, were used. In addition, a representative Cuban CSF isolate was assessed in an experimental infection trial for their clinical virulence in order to expand the knowledge regarding CSF viruses circulating in pig populations. The viral genomes sequenced in this study were grouped in a defined cluster within the genotype 1.2, as it has been reported previously for Cuban CSF viruses. The selection pressure analys...Continue Reading

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Citations

Mar 25, 2014·Virus Research·Joan TarradasLlilianne Ganges
Mar 11, 2016·Cell Host & Microbe·Troels K H ScheelCharles M Rice
Jul 15, 2015·Veterinary Research·Sara Muñoz-GonzálezLlilianne Ganges
Mar 10, 2015·Preventive Veterinary Medicine·Lester J PérezHeidy Díaz de Arce
Apr 22, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Wei JiCheng-Qiang He
Dec 22, 2017·Scientific Reports·Liliam RiosLester J Pérez
Aug 11, 2017·Transboundary and Emerging Diseases·Alexander PostelPaul Becher
Nov 21, 2018·Transboundary and Emerging Diseases·José Alejandro BohórquezLlilianne Ganges
Aug 3, 2017·BMC Veterinary Research·Oscar CabezónLlilianne Ganges
Apr 4, 2017·Journal of Veterinary Research·Chaoliang LengZhijun Tian
Aug 16, 2016·Journal of Veterinary Science·Seong-In LimDong-Jun An
Mar 3, 2020·Frontiers in Veterinary Science·Osvaldo Fonseca-RodríguezMaría Irian Percedo
Mar 11, 2021·Veterinary Immunology and Immunopathology·Marisela Suárez-PedrosoMario Pablo Estrada-García
Jul 29, 2021·Veterinary World·Sharanagouda S PatilBibek Ranjan Shome

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