Positive staining of the immunoligand B7-H6 in abnormal/transformed keratinocytes consistently accompanies the progression of cervical cancer.

BMC Immunology
Gloria Yareli Gutierrez-SilerioSusana Del Toro-Arreola

Abstract

B7-H6 has been revealed as an endogenous immunoligand expressed in a variety of tumors, but not expressed in healthy tissues. Heretofore, no studies have been reported describing B7-H6 in women with cervical cancer. To investigate this question, our present study was conducted. This retrospective study comprised a total of 62 paraffinized cervical biopsies, which were distributed in five groups: low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), squamous cervical carcinoma (SCC), uterine cervical adenocarcinoma (UCAC), and a group of cervicitis (as a control for non-abnormal/non-transformed cells). Cervical sections were stained by immunohistochemistry to explore the expression of B7-H6, which was reported according to the immunoreactive score (IRS) system. We observed a complete lack of B7-H6 in LSIL abnormal epithelial cells. Interestingly, B7-H6 began to be seen in HSIL abnormal epithelial cells; more than half of this group had B7-H6 positive cells, with staining characterized by a cytoplasmic and membranous pattern. B7-H6 in the SCC group was also seen in the majority of the sections, showing the same cytoplasmic and membranous pattern. Strong evidence of B7-H6 was notabl...Continue Reading

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Citations

Nov 22, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hao QiuJiamin Wang
Nov 27, 2020·OncoTargets and Therapy·Hongyan ChengYang Xiang
Jul 20, 2021·Genetic Testing and Molecular Biomarkers·Xuejing LiuYanying Xu

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Methods Mentioned

BETA
biopsies
transgenic

Software Mentioned

SPSS

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