Positive symptoms and duration of illness predict functional laterality and attention modulation in schizophrenia

Acta Psychiatrica Scandinavica
E-M LøbergKenneth Hugdahl

Abstract

Dichotic listening (DL) performance in schizophrenia, reflecting hemispheric asymmetry and the functional integrity of the left temporal lobe, can vary with clinical characteristics. Previous studies have not taken the co-linearity of clinical variables into account. The aim of the present study was to evaluate the roles of positive symptoms and duration of illness in DL through Structural Equation Modeling (SEM), thus allowing for complex relationships between the variables. We pooled patients from four previous DL studies to create a heterogeneous group of 129 schizophrenic patients, all tested with a consonant-vowel syllables DL procedure that included attentional instructions. A model where positive symptoms predicted a laterality component and duration of illness predicted an attention component in DL was confirmed. Positive symptoms predicted reduced functional laterality, suggesting involvement of left temporal lobe language processing. Duration of illness predicted impaired attention modulation, possibly reflecting the involvement of frontotemporal networks.

References

Mar 1, 1979·Archives of General Psychiatry·B E Wexler, G R Heninger
Aug 1, 1992·The American Journal of Psychiatry·J M CleghornE S Garnett
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P F LiddleR S Frackowiak
Feb 1, 1992·The American Journal of Psychiatry·J TiihonenM Kajola
Nov 1, 1990·The American Journal of Psychiatry·P E BartaL E Tune
Sep 1, 1986·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·K Hugdahl, L Andersson
May 1, 1995·Schizophrenia Research·K Maurer, H Häfner
Jun 1, 1995·Brain and Language·A E Asbjørnsen, K Hugdahl
Feb 1, 1993·The American Journal of Psychiatry·M F Green
Dec 1, 1995·Scandinavian Journal of Psychology·K JariabkováJ Glós
Jul 1, 1995·Journal of Psychiatric Research·M FlaumN C Andreasen
Aug 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·P K McGuireC D Frith
Feb 1, 1996·The Australasian Journal of Dermatology·M N Gillet-TerverJ L Schmutz
Aug 1, 1997·Trends in Neurosciences·T J Crow
Dec 31, 1997·Journal of Clinical and Experimental Neuropsychology·K Hugdahl, A Hammar
Feb 14, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·G D Pearlson
Feb 19, 1998·Schizophrenia Research·T J Crow
Jan 23, 1999·Biological Psychiatry·E M LøbergM F Green
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·R J DolanC D Frith
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·K J Friston
Sep 10, 1999·Acta Psychiatrica Scandinavica·B R Rund, N E Borg
Mar 9, 2000·Schizophrenia Research·R P RajarethinamR Tandon
Nov 18, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·D MalaspinaR Van Heertum
Nov 25, 2000·Psychiatry Research·B R LennoxP B Jones
Apr 3, 2001·The American Journal of Psychiatry·N J BlackwoodR M Murray
May 30, 2001·Schizophrenia Research·M StephaneN N Boutros

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Citations

Jan 24, 2012·Cognitive Neuropsychiatry·Daniela A HerzigChristine Mohr
Oct 26, 2010·BMC Research Notes·Tanya N Beran, Claudio Violato
Mar 15, 2015·Nordic Journal of Psychiatry·Alfredo Carlo AltamuraMassimiliano Buoli
Jul 16, 2010·Journal of Behavior Therapy and Experimental Psychiatry·Daniela A HerzigChristine Mohr
Nov 12, 2014·Cognitive Neuropsychiatry·Else-Marie LøbergErik Johnsen
Mar 8, 2017·Schizophrenia Research·Tumbwene E MwansisyaZhening Liu
Jul 5, 2013·American Journal of Audiology·Vasiliki Vivian IliadouApostolos Iacovides
Aug 28, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Timothea ToulopoulouAnthony S David
Jan 23, 2018·Scandinavian Journal of Psychology·Kenneth Hugdahl
Nov 26, 2020·Neuropsychologia·Shira Russell-GillerJin Fan

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