Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy

Journal of the American Chemical Society
Yan LiXin Zhang

Abstract

Due to the vast differences in chemical properties among small molecule drugs, nucleotide drugs, and superparamagnetic iron oxide nanocubes (SPIONs), such as charge and hydrophobicity, entrapment of these within a single carrier for traceable synergistic therapy has been proven difficult. Herein, we synthesize positively charged polyprodrug amphiphiles. The hydrophobic polyprodrug unit of the amphiphiles is positively charged, which can simultaneously load hydrophobic SPIONs and absorb negative let-7b antisense oligonucleotide to construct traceable co-delivery nanoparticles (NPs). This characteristic avoids the use of inert materials and enhances drug loading of the traceable NPs. The traceable NPs can achieve controlled release of drugs to reduce the differentiation of exogenous neural stem cells (NSCs) and enhance their secretion of brain-derived neurotrophic factor (BDNF) synergistically. Exogenous NSCs treated with the NPs significantly rescue the memory deficits in 2xTg-AD mice. In addition, the transplantation site and migration of exogenous NSCs can be traced using the SPIONs with high r2 value for magnetic resonance imaging. Therefore, traceable NPs self-assembled from the positively charged polyprodrug amphiphiles may...Continue Reading

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Citations

Dec 5, 2018·Advanced Materials·Xiao-Li LiuXing-Jie Liang
Dec 24, 2018·Expert Opinion on Drug Delivery·Manju SharmaJiban Jyoti Panda
Jan 21, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tian ZhangZhigang Xu
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Sep 6, 2020·International Journal of Molecular Sciences·Gengqi LiuYumiao Zhang
Jan 20, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lingxiao ZhangDaishun Ling
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Apr 17, 2021·Drug Delivery and Translational Research·Zhengyu Deng, Shiyong Liu
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Aug 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yihenew Simegniew Birhan, Hsieh-Chih Tsai
Mar 28, 2020·Current Stem Cell Research & Therapy·Weitong CuiTianxu Zhang

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