PMID: 6972094Jan 1, 1981Paper

Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine

Seminars in Nuclear Medicine
M E Phelps

Abstract

The capability of positron computed tomography (PCT) to delineate the substructures of the brain and its facility for accurately measuring the local tissue radioactivity concentration allow the application of tracer kinetic models for the study of local cerebral function in man. This principle and an adaptation of the 14C-deoxyglucose (DG) model of Sokoloff et al. with 18F-2-fluoro-deoxy-D-glucose (FDG) is being used at UCLA. Brookhaven National Laboratory, University of Pennsylvania, NIH, and the Massachusetts General Hospital to determine the local cerebral glucose metabolic rate (LCMRGIc) in normal man at rest and during sensory activation and the changes that occur in patients with a variety of cerebral disorders. Kinetic studies with PCT have been employed to measure the rate constants of the model in different gray and white matter structures of the brain in both normal and ischemic states. The precision of the method in normals has been shown to be about +/- 5% for 1.5-2.0 sq cm regions of the brain. Studies in normals have yielded values for hemispheric CMRGIc that are in agreement with measurement using the Kety-Schmidt technique and LCMRGIc values in agreement with values in monkeys using DG autoradiography. Studies i...Continue Reading

References

Oct 1, 1978·Annals of Neurology·C KennedyL Sokoloff
Jun 1, 1979·Journal of Computer Assisted Tomography·E J HoffmanM E Phelps
Dec 1, 1975·Circulation Research·J O EichlingM M Ter-Pogossian
Oct 1, 1977·Seminars in Nuclear Medicine·M E Phelps
Jun 1, 1975·The American Journal of Physiology·M E RaichleM M Ter-Pogossian
Jan 1, 1975·Radiology·M M Ter-PogossianN A Mullani
Jan 1, 1972·Anesthesiology·H TakeshitaA Sari
Aug 1, 1967·Journal of Applied Physiology·P J CohenH Wollman

❮ Previous
Next ❯

Citations

Mar 12, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Emilie MaceMickael Tanter
Jan 1, 1987·IEEE Transactions on Medical Imaging·J M Ollinger
Jan 1, 1985·Annals of the New York Academy of Sciences·J C Mazziotta
Jun 14, 2013·BioMed Research International·Adomas BuneviciusWeili Lin
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C ClarkR Cohen
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M E PhelpsS C Huang
Feb 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mary Louise HarrisShaheen Hamdy
Jun 1, 1988·Cancer Metastasis Reviews·R A Hawkins, M E Phelps
Aug 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahueJeroen Hendrikse
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·D GurE E Cook
Mar 30, 2007·Arthritis and Rheumatism·B KulkarniA K P Jones
Feb 23, 2011·Imaging in Medicine·Shan TongPaul E Kinahan
Dec 13, 2006·Development and Psychopathology·Catherine C AyoubDante Cicchetti
Jan 1, 1984·Neurosurgical Review·Y L YamamotoW H Feindel
Mar 3, 2017·Nature Materials·José Fernando Maya-VetencourtFabio Benfenati
Dec 1, 1982·Journal of Medical Systems·M M Ter-Pogossian
Dec 24, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jean F SoustielDan Manor
Jul 1, 2020·Nature Nanotechnology·José Fernando Maya-VetencourtFabio Benfenati
Jun 18, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bradley T ChristianCharles A Mistretta
Mar 11, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Letizia ZulloGianmario Sambuceti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.