Positron emission tomographic evaluation of cerebral blood flow during state anxiety in simple phobia

Archives of General Psychiatry
J M MountzD E Kuhl

Abstract

The present study was undertaken to clarify some of the conflicting findings of previous reports on the effect of state anxiety on cerebral blood flow (CBF). Seven subjects with simple phobia of small animals were studied to permit the generation of wide ranges of anxiety. Each subject received five positron emission tomography (PET) scans in a rest-fear-rest-fear-rest, repeated-measures paradigm. A population of eight normal controls was employed. The phobic stimuli produced significant increases in state anxiety during fear and significant differences in physiologic measurements between the fear and rest scans. Absolute global and regional CBF was significantly lower during fear scans than during rest scans; however, when hypocapnia resulting from anxiety-induced hyperventilation was taken into account, the pattern vanished, and all global and regional CBF differences among scans became not significant. Resting global and regional CBF values in the phobic subjects did not significantly differ from those of the normal controls. That a relationship between anxiety and CBF was not found in 35 scans among seven subjects strongly suggests that CBF changes induced by state anxiety are either not presently measurable by PET techniqu...Continue Reading

Citations

Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·L CahillJ L McGaugh
Aug 30, 2008·Journal of Neural Transmission·Georg W AlpersRudolf Stark
Dec 29, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·L Dratcu
Apr 1, 1990·Psychiatry Research·B GiordaniD E Kuhl
Feb 13, 2001·Biological Psychiatry·J K RillingC D Kilts
Apr 1, 1993·Biological Psychiatry·M T De CristofaroC Faravelli
Apr 28, 2004·Biological Psychiatry·Scott L RauchBruce Fischl
Jun 21, 1997·Annals of the New York Academy of Sciences·S L Rauch, L M Shin
Jul 19, 2012·Psychiatry Research·Antonio Del CasalePaolo Girardi
Apr 1, 2010·PET Clinics·Andrew B Newberg, Abass Alavi
Jun 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J M StapletonE D London
Aug 8, 2007·NeuroImage·Thomas StraubeWolfgang H R Miltner
Feb 13, 2007·Comprehensive Psychiatry·Nicholas D GiardinoStephen R Dager
May 18, 2005·Psychiatry and Clinical Neurosciences·Dattatrey Namdeorao MendhekarAnil Kumar Singh
Dec 16, 2004·Psychiatry Research·Dick J VeltmanPaul M G Emmelkamp
Sep 6, 2005·Biological Psychiatry·Thomas StraubeWolfgang H R Miltner
Aug 10, 2005·NeuroImage·Thomas StraubeWolfgang H R Miltner
Apr 1, 1997·Biological Psychiatry·R J MathewK E Wiethe
Apr 1, 1991·Seminars in Nuclear Medicine·A P YuddJ C Masdeu
Mar 7, 2012·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ila M P LinaresJosé Alexandre S Crippa
May 21, 1999·NeuroImage·P ChuaR Dolan
Sep 1, 1992·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J NaveteurM Steinling
Nov 1, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·L Dratcu
Nov 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A DahlK Rootwelt
Jan 1, 1993·Psychophysiology·M FredriksonG Sedvall
May 2, 2003·Annals of the New York Academy of Sciences·Mats Fredrikson, Tomas Furmark
Jul 1, 1994·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·V A KnappertzC H Tegeler

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