Positron Emission Tomography-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ulrich DührsenPETAL Trial Investigators

Abstract

Purpose Interim positron emission tomography (PET) using the tracer, [18F]fluorodeoxyglucose, may predict outcomes in patients with aggressive non-Hodgkin lymphomas. We assessed whether PET can guide therapy in patients who are treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Patients and Methods Newly diagnosed patients received two cycles of CHOP-plus rituximab (R-CHOP) in CD20-positive lymphomas-followed by a PET scan that was evaluated using the ΔSUVmax method. PET-positive patients were randomly assigned to receive six additional cycles of R-CHOP or six blocks of an intensive Burkitt's lymphoma protocol. PET-negative patients with CD20-positive lymphomas were randomly assigned or allocated to receive four additional cycles of R-CHOP or the same treatment with two additional doses rituximab. The primary end point was event-free survival time as assessed by log-rank test. Results Interim PET was positive in 108 (12.5%) and negative in 754 (87.5%) of 862 patients treated, with statistically significant differences in event-free survival and overall survival. Among PET-positive patients, 52 were randomly assigned to R-CHOP and 56 to the Burkitt protocol, with 2-year event-free survival rates of 4...Continue Reading

Associated Clinical Trials

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Citations

Aug 21, 2018·Leukemia & Lymphoma·Piers Blombery, Sarah-Jane Dawson
Sep 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulrich DührsenAndreas Hüttmann
Sep 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hugo J A Adams, Thomas C Kwee
Sep 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Reid W Merryman, Ann LaCasce
Sep 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christian Gisselbrecht
Feb 28, 2019·Current Hematologic Malignancy Reports·Jennifer Crombie, Philippe Armand
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Mar 11, 2020·Cancers·Conrad-Amadeus VoltinDirk Hellwig
Feb 14, 2020·Der Radiologe·Stefan KasperJan Philipp Radtke
Jun 20, 2020·Blood·Michel Meignan, Andrea Gallamini
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Apr 3, 2021·Therapeutic Advances in Hematology·Myrna Candelaria, Alfonso Dueñas-Gonzalez
Apr 29, 2021·Seminars in Hematology·Mary-Kate Malecek, Neha Mehta-Shah
Apr 29, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan AligAsh A Alizadeh
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Nov 24, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tamás GyörkeStefano Fanti
May 10, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jan RekowskiUlrich Dührsen

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