Positron emission tomography imaging for the assessment of mild traumatic brain injury and chronic traumatic encephalopathy: recent advances in radiotracers.

Neural Regeneration Research
Chu-Xin HuangJun Liu

Abstract

A chronic phase following repetitive mild traumatic brain injury can present as chronic traumatic encephalopathy in some cases, which requires a neuropathological examination to make a definitive diagnosis. Positron emission tomography (PET) is a molecular imaging modality that has high sensitivity for detecting even very small molecular changes, and can be used to quantitatively measure a range of molecular biological processes in the brain using different radioactive tracers. Functional changes have also been reported in patients with different forms of traumatic brain injury, especially mild traumatic brain injury and subsequent chronic traumatic encephalopathy. Thus, PET provides a novel approach for the further evaluation of mild traumatic brain injury at molecular levels. In this review, we discuss the recent advances in PET imaging with different radiotracers, including radioligands for PET imaging of glucose metabolism, tau, amyloid-beta, γ-aminobutyric acid type A receptors, and neuroinflammation, in the identification of altered neurological function. These novel radiolabeled ligands are likely to have widespread clinical application, and may be helpful for the treatment of mild traumatic brain injury. Moreover, PET f...Continue Reading

References

Jul 1, 1989·Histopathology·J H AdamsD R McLellan
Feb 1, 1987·Journal of Neurosurgery·H S LevinR F Frankowski
Jan 1, 1996·The Journal of Neuropsychiatry and Clinical Neurosciences·H GrossH Lavretsky
Nov 8, 2002·Archives of Physical Medicine and Rehabilitation·Eric M UmileRosette C Plotkin
Dec 12, 2002·Cellular and Molecular Life Sciences : CMLS·N Shahani, R Brandt
Feb 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S H A ChenG D Hutchins
Jun 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·S FlemingerA Giora
Mar 24, 2004·Seminars in Cell & Developmental Biology·Michel Goedert
Mar 28, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Tohru ShigaNagara Tamaki
Mar 11, 2010·Nature Reviews. Neuroscience·Victoria E JohnsonDouglas H Smith
Jun 3, 2011·Synapse·Philip Seeman, Neil Seeman
Sep 3, 2011·AJNR. American Journal of Neuroradiology·E RazM Inglese
Jan 31, 2012·Experimental Neurology·Victoria E JohnsonDouglas H Smith
Jan 1, 2011·BMJ Case Reports·Masaki NishidaToru Nishikawa
Jan 25, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Gary W SmallJorge R Barrio
Jul 9, 2013·Journal of Neurotrauma·Reed SelwynKimberly R Byrnes
Oct 15, 2013·Medical Hypotheses·Leslie M Klevay
Jan 11, 2014·Frontiers in Neuroenergetics·Kimberly R ByrnesReed G Selwyn
Jan 21, 2014·Academic Radiology·Søren HessAbass Alavi
Jan 21, 2014·Progress in Neurobiology·Ivo F ScheiberRalf Dringen
Jun 21, 2014·The American Journal of Forensic Medicine and Pathology·Shudong YangHuijun Mu
Dec 3, 2014·Neurobiology of Disease·Jennifer M CoughlinMartin G Pomper
Apr 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jorge R BarrioVladimir Kepe
May 7, 2015·Acta Neuropathologica·Thor D SteinAnn C McKee
Jun 27, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fangyu PengRamon Diaz-Arrastia
Dec 4, 2015·Nature Reviews. Neuroscience·Yipeng Wang, Eckhard Mandelkow
May 18, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Luke C HenryLouis De Beaumont
Aug 17, 2016·CNS & Neurological Disorders Drug Targets·Mohammad NasserFiras Kobeissy
Aug 28, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Cyrus A RajiGary W Small
Sep 18, 2016·Neurosurgery Clinics of North America·Melissa J McGinn, John T Povlishock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.