Positron emission tomography imaging in multiple sclerosis-current status and future applications.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
L KiferleP Piccini

Abstract

Multiple Sclerosis (MS) is traditionally considered as a central nervous system (CNS) white matter inflammatory disease. However, recent studies have focused on the neurodegenerative aspects of the disease, which occur early in the pathological process, providing an opportunity for therapeutic intervention and application of neuroprotective strategies. The relationship between neural inflammation and cell death remains controversial. The recent development of new radiolabelled ligands provides positron emission tomography (PET) imaging with a role for studying early aspects of the MS pathology. We provide an overview of current PET research in MS, particularly focussing on possible applications of new radioligands for studying inflammation and neurodegenerative processes. Pathological aspects of neuroinflammation, axonal degeneration and neuronal repair may be explored in vivo with selective PET tracers. Specific radioligands for the cannabinoid system may be applied in MS research to understand the role of this neurotransmitter system in the pathogenesis of the disease. PET imaging represents a promising tool for elucidating controversial aspects of MS pathology and for the assessment of selective and potentially neuroprotecti...Continue Reading

References

Oct 1, 1992·Journal of the Neurological Sciences·C PozzilliN Canal
Aug 30, 2000·Lancet·H W StraussF G Blankenberg
May 31, 2002·Pharmacological Reviews·A C HowlettR G Pertwee
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J C DebruyneJ L De Reuck
Jul 24, 2003·Brain : a Journal of Neurology·Gareth PryceDavid Baker
Mar 30, 2004·Annals of Neurology·Michael H Barnett, John W Prineas
Mar 12, 2005·Cellular and Molecular Life Sciences : CMLS·R F A ZwaalE M Bevers
Apr 22, 2005·Brain : a Journal of Neurology·M R TurnerP N Leigh
May 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Rohit BakshiJerry S Wolinsky
May 3, 2006·Journal of the Neurological Sciences·Per Soelberg SørensenMads Ravnborg
May 11, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoko IkomaKazutoshi Suzuki
May 20, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Chunying WuYanming Wang
Aug 22, 2006·Brain : a Journal of Neurology·Peter PatrikiosHans Lassmann
Dec 21, 2006·Nature Reviews. Neuroscience·Michelle L BlockJau-Shyong Hong
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina BenitoJulián Romero
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fumihiko YasunoRobert B Innis
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·H Donald BurnsRichard J Hargreaves
Jul 11, 2007·Journal of Neuropathology and Experimental Neurology·Riccardo Cassiani-IngoniMahendra S Rao
Jan 23, 2008·Expert Opinion on Therapeutic Targets·Fabian DocagneCarmen Guaza
Feb 23, 2008·Molecular and Cellular Endocrinology·Javier Fernández-RuizJosé A Ramos
Jun 19, 2008·Annual Review of Neuroscience·Bruce D Trapp, Klaus-Armin Nave
Oct 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Fabien ChauveauBertrand Tavitian
Oct 11, 2008·Journal of Medicinal Chemistry·Chunying WuYanming Wang
Nov 1, 2008·Nature Reviews. Drug Discovery·Rocio S Lopez-Diego, Howard L Weiner
Feb 4, 2009·Archives of General Psychiatry·Koen Van LaereGuido Pieters
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yanming WangRobert H Miller

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Citations

Feb 3, 2012·Journal of Neurology·Marios Politis, Paola Piccini
Nov 8, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas Tourdias, Vincent Dousset
Nov 19, 2013·Best Practice & Research. Clinical Rheumatology·César Magro ChecaGerda M Steup-Beekman
Sep 14, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H Schapira, M Hillbom
Apr 29, 2011·Progress in Neurobiology·Ulf ZiemannHayrettin Tumani
May 3, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andreas H JacobsUNKNOWN INMiND consortium
Mar 23, 2011·The Mount Sinai Journal of Medicine, New York·Jeffery D HainesPatrizia Casaccia
Mar 27, 2015·Journal of Neurology·Lorenzo RocchiMarios Politis
May 2, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Adam J RosenbergZhude Tu
Dec 6, 2014·Frontiers in Cellular Neuroscience·Eva Mracsko, Roland Veltkamp
Oct 4, 2016·Frontiers in Molecular Neuroscience·Pekka PoutiainenAnna-Liisa Brownell
Dec 15, 2015·International Anesthesiology Clinics·Murielle KirschVincent Bonhomme
Apr 2, 2014·Clinical Nuclear Medicine·Anna Margherita MaffioneDomenico Rubello
Feb 25, 2014·Clinical Nuclear Medicine·Flavia NiccoliniMarios Politis
Feb 9, 2018·Cold Spring Harbor Perspectives in Medicine·Elaine O'LoughlinOleg Butovsky
Mar 1, 2012·Expert Review of Neurotherapeutics·Claire RileyDaniel Pelletier
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Matteo BaucknehtSilvia Morbelli

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