Jan 1, 1986

Positron emission tomography imaging of regional cerebral glucose metabolism

Seminars in Nuclear Medicine
A AlaviM Reivich


The (F-18) fluorodeoxyglucose (FDG) technique to measure local cerebral metabolic rate for glucose (LCMRglu) is well accepted and widely used by many institutions around the world. A large number of studies has been carried out in normal volunteers and patients with a variety of CNS disorders. Several investigators have noted that no significant age-related changes in cerebral glucose use occur with normal aging. Some important and interesting findings have been revealed following sensory, motor, visual, and auditory stimulations. Functional imaging with FDG in certain neurologic disorders has dramatically improved our understanding of their underlying pathophysiologic phenomena. Some abnormalities detected on the positron emission tomography (PET) images have no corresponding changes on either x-ray computed tomograms (XCT) or magnetic resonance images (MRI). In patients with Alzheimer's disease, primary sensorimotor, visual, and cerebellar metabolic activity appears relatively preserved. In contrast, parietal, temporal, and to some degree, frontal glucose metabolism is significantly diminished even in the early stages of the disease. Patients with Huntington's disease and those at risk of developing this disorder have a typic...Continue Reading

  • References55
  • Citations33


  • References55
  • Citations33


Mentioned in this Paper

Senile Paranoid Dementia
Metabolic Process, Cellular
Congenital Structural Myopathy
Cerebrovascular Occlusion
Positron-Emission Tomography
Huntington's Disease Pathway
Plain X-ray

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