PMID: 9430315Jan 16, 1998Paper

Positron emission tomography in children with neurofibromatosis-1

Journal of Child Neurology
A M KaplanE M Reiman

Abstract

Neurofibromatosis-1 is an autosomal dominant genetic disorder commonly associated with neuropsychological complications. Focal areas of high signal intensity on magnetic resonance imaging (MRI) scans occur commonly but have shown inconsistent correlation with neuropsychological problems. Positron emission tomography (PET) scans utilizing [18F]fluoro-2-deoxy-D-glucose and MRI studies were performed on 10 children with neurofibromatosis-1 and multiple focal areas of high signal intensity to evaluate the regional cerebral metabolic rate for glucose of these lesions and other central nervous system structures. Co-registered PET and MRI studies confirmed reduced glucose metabolism of large focal areas of high signal intensity. Visual inspection and semiquantitative analysis of PET images demonstrated thalamic hypometabolism and varying degrees of cortical inhomogeneity in all cases of neurofibromatosis-1 compared to normal controls. Although a primary defect of the thalamus or cerebral cortex has not been defined, the metabolic abnormalities of this study suggest a potential relationship between these structures and the neuropsychological dysfunctions noted in neurofibromatosis-1.

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Citations

Feb 25, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Mahendranath MoharirKathryn North
Dec 1, 2007·Nuclear Medicine Communications·Ralph BuchertVictor F Mautner
Feb 15, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Shelley L HymanKathryn N North
Jun 15, 2013·AJNR. American Journal of Neuroradiology·K W YeomC J Campen
Mar 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ivayla ApostolovaRalph Buchert
Sep 4, 2015·Brain Research·Ivayla ApostolovaRalph Buchert
Sep 1, 2012·Developmental Medicine and Child Neurology·Annukka LehtonenSusan M Huson
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C NanniS Fanti
Aug 21, 2007·Seminars in Nuclear Medicine·Shekhar PatilLise Borgwardt
Feb 15, 2013·Journal of Neurodevelopmental Disorders·Inês R ViolanteMiguel Castelo-Branco
Feb 17, 2001·American Journal of Medical Genetics·K North

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