Positron emission tomography measurement of tumor metabolism and growth: its expanding role in oncology

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Anthony F Shields

Abstract

This work highlights the explosion and evolution of positron emission tomography (PET) for use in oncology research and clinical practice. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-PET is important in the staging of cancer, estimation of prognosis, and for its ability to predict therapeutic outcome. A number of new imaging agents are under development and may find a place in oncology when studies prove their utility. This scientific overview includes a review of the development of a number of thymidine analogs, such as 18F-3'-deoxy-3'-fluorothymidine (FLT) and 18F-1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-thymine (FMAU), including chemical structure variations; their application in a variety of tumors; and the role of various kinetic models for understanding cellular proliferation. The greatest unmet need for PET is in further developing and validating its use in the measurement of treatment response.

References

Apr 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D ChristmanA P Wolf
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Jan 1, 1981·Cancer·A B MillerA Winkler
Nov 11, 1998·Nature Medicine·A F ShieldsT J Mangner
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J F VansteenkisteM G Demedts
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E MortimerM J Welch
Jan 14, 2003·Seminars in Nuclear Medicine·I Ho ShonM N Maisey
Jan 16, 2003·Chest·George R SimonUNKNOWN American College of Chest Physicians
Feb 18, 2003·European Journal of Nuclear Medicine and Molecular Imaging·E FrickeA R Boerner
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Farrokh DehdashtiMichael J Welch
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P Mac ManusDavid L Ball
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oday HamidAnthony F Shields
Sep 6, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S StroobantsA van Oosterom
Mar 30, 1957·Nature·C HEIDELBERGERJ SCHEINER
Dec 10, 2003·American Journal of Clinical Oncology·Sana Al-SukhunAnthony F Shields
Feb 13, 2004·International Journal of Cancer. Journal International Du Cancer·Wouter H de Vos tot Nederveen CappelHans F A Vasen
Mar 12, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Mei TianKeigo Endo
May 6, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Andreas K BuckSven N Reske
Dec 9, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Haihao SunAnthony F Shields
Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ryohei SasakiJames D Cox
May 13, 2005·The New England Journal of Medicine·Anna Bill-AxelsonUNKNOWN Scandinavian Prostate Cancer Group Study No. 4
Jul 2, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Anthony F ShieldsOtto Muzik
Aug 13, 2005·The Breast : Official Journal of the European Society of Mastology·Chandra N BurgeSophia K Apple
Oct 18, 2005·Surgical Oncology Clinics of North America·Claudia I Henschke, UNKNOWN I-ELCAP Investigators
Nov 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S M EschmannR Bares

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Citations

Apr 4, 2007·Journal of Bioenergetics and Biomembranes·Peter L Pedersen
Dec 22, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zi-Bo LiXiaoyuan Chen
May 23, 2009·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·T EbenhanP M J McSheehy
Dec 15, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sarah R MuddYanping Luo
Mar 19, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M T Macías
Jan 29, 2013·Clinical Nuclear Medicine·Virendra KumarEdward A Eikman
Jul 25, 2012·AJR. American Journal of Roentgenology·Hossein Jadvar
Feb 18, 2010·Biomarkers in Medicine·Andrea L Merz, Natalie J Serkova
Apr 4, 2014·World Journal of Gastroenterology : WJG·Koichi HayanoDushyant V Sahani
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Van M SavageGeoffrey B West
Feb 26, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Felipe A CalvoJosé L Carreras
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Anil Arora, Ashish Kumar
Jun 25, 2009·Journal of Oncology·Franziska GrafJens Pietzsch
Mar 15, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Teresa A SzyszkoGary J R Cook
Feb 18, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Claudio V SoleJose L Carreras
Mar 1, 2016·Nuclear Medicine and Biology·Shaobo YaoFang Li
Nov 1, 2010·Insights Into Imaging·Egesta LopciStefano Fanti
Jan 3, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Dmitry SolovievEric Aboagye
Aug 17, 2010·Antiviral Research·Mike BrayElaine Jagoda
Jun 15, 2010·Clinical Radiology·C NanniS Fanti
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·James A HaymanMichael Mac Manus
Nov 11, 2008·The Urologic Clinics of North America·Rodolfo PeriniChaitanya Divgi
Jan 1, 2007·PET Clinics·Homer A Macapinlac
Dec 27, 2007·Nuclear Medicine and Biology·Peter S ContiJames H Anderson
Dec 7, 2006·Neuroimaging Clinics of North America·Homer A Macapinlac
Dec 5, 2006·Biochimica Et Biophysica Acta·André A Neves, Kevin M Brindle
Oct 18, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Pei-Chia ChanHsin-Ell Wang
May 15, 2015·The Indian Journal of Radiology & Imaging·Koichi HayanoDushyant V Sahani
Jun 18, 2016·International Journal of Molecular Imaging·Danny L CostantiniMartin Charron
Feb 16, 2018·Science Translational Medicine·William C StaffordElias S J Arnér
Apr 6, 2011·Health Physics·Yoshimune OgataHajime Nakamura

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