Positron emission tomography (PET) evaluation after initial chemotherapy and radiation therapy predicts local control in rhabdomyosarcoma

International Journal of Radiation Oncology, Biology, Physics
Kavita V DharmarajanSuzanne L Wolden

Abstract

18-fluorodeoxyglucose positron emission tomography (PET) is already an integral part of staging in rhabdomyosarcoma. We investigated whether primary-site treatment response characterized by serial PET imaging at specific time points can be correlated with local control. We retrospectively examined 94 patients with rhabdomyosarcoma who received initial chemotherapy 15 weeks (median) before radiotherapy and underwent baseline, preradiation, and postradiation PET. Baseline PET standardized uptake values (SUVmax) and the presence or absence of abnormal uptake (termed PET-positive or PET-negative) both before and after radiation were examined for the primary site. Local relapse-free survival (LRFS) was calculated according to baseline SUVmax, PET-positive status, and PET-negative status by the Kaplan-Meier method, and comparisons were tested with the log-rank test. The median patient age was 11 years. With 3-year median follow-up, LRFS was improved among postradiation PET-negative vs PET-positive patients: 94% vs 75%, P=.02. By contrast, on baseline PET, LRFS was not significantly different for primary-site SUVmax≤7 vs >7 (median), although the findings suggested a trend toward improved LRFS: 96% for SUVmax≤7 vs 79% for SUVmax>7, P=...Continue Reading

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Citations

Dec 12, 2013·Current Opinion in Pediatrics·Douglas S HawkinsErin R Rudzinski
Oct 8, 2013·The Orthopedic Clinics of North America·Mihir M Thacker
Jul 6, 2013·The Orthopedic Clinics of North America·Mihir M Thacker
Oct 2, 2012·International Journal of Radiation Oncology, Biology, Physics·Joanna C YangSuzanne L Wolden
Oct 28, 2014·Pediatric Blood & Cancer·Dana L CaseySuzanne L Wolden
Apr 18, 2014·Pediatric Blood & Cancer·Renaud MazeronChristine Haie-Méder
Dec 30, 2014·International Journal of Radiation Oncology, Biology, Physics·Dana L CaseySuzanne L Wolden
Jun 24, 2015·PET Clinics·Sara SheikhbahaeiRathan M Subramaniam
Dec 24, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Abby R RosenbergDouglas S Hawkins
May 18, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y-J LiC-Q Tu
Nov 2, 2018·The British Journal of Radiology·Greg ChambersAndrew Scarsbrook
Oct 18, 2019·Pediatric Radiology·Noorulhuda Jawad, Kieran McHugh
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Aug 14, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Federico MercoliniGianni Bisogno

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