Positron emission tomography response evaluation from a randomized phase III trial of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone for patients with metastatic adenocarcinoma of the pancreas

Annals of Oncology : Official Journal of the European Society for Medical Oncology
Ramesh K RamanathanDaniel D Von Hoff

Abstract

In the phase III MPACT trial, nab-paclitaxel plus gemcitabine (nab-P + Gem) demonstrated superior efficacy versus Gem alone for patients with metastatic pancreatic cancer. We sought to examine the feasibility of positron emission tomography (PET) and to compare metabolic response rates and associated correlations with efficacy in the MPACT trial. Patients with previously untreated metastatic adenocarcinoma of the pancreas were randomized 1:1 to receive nab-P + Gem or Gem alone. Treatment continued until disease progression by RECIST or unacceptable toxicity. PET scans were carried out on the first 257 patients enrolled at PET-equipped centers (PET cohort). Most patients (252 of 257) had ≥2 PET-avid lesions, and median maximum standardized uptake values at baseline were 4.6 and 4.5 in the nab-P + Gem and Gem-alone arms, respectively. In a pooled treatment arm analysis, a metabolic response by PET (best response at any time during study) was associated with longer overall survival (OS) (median 11.3 versus 6.9 months; HR, 0.56; P < 0.001). Efficacy results within each treatment arm appeared better for patients with a metabolic response. The metabolic response rate (best response and week 8 response) was higher for nab-P + Gem (bes...Continue Reading

References

Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Jun 15, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gerben R BorstJoos V Lebesque
Nov 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S M EschmannR Bares
Apr 17, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·K A WoodM I Saunders
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John O PriorSerge Leyvraz
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffManuel Hidalgo
Dec 5, 2012·Seminars in Radiation Oncology·Abraham J Wu, Karyn A Goodman
Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hubert PiessevauxSabine Tejpar
Oct 18, 2013·The New England Journal of Medicine·Daniel D Von HoffMarkus F Renschler
Feb 2, 2015·Journal of the National Cancer Institute·David GoldsteinDaniel D Von Hoff

❮ Previous
Next ❯

Citations

Jun 1, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R K RamanathanD D Von Hoff
Jun 4, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jean-Baptiste BachetJean-Luc Van Laethem
Jul 23, 2014·Critical Reviews in Oncology/hematology·A ViúdezM Hidalgo
May 9, 2014·Clinical Breast Cancer·Stefan Glück
Feb 25, 2014·Cancer Treatment Reviews·Christine MegerdichianSara A Hurvitz
May 18, 2017·Journal of Surgical Oncology·Jad Abou-Khalil, Flavio G Rocha
Aug 5, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Ronald L KornRamesh K Ramanathan
Aug 24, 2017·Acta Oncologica·Evelyn E C de JongAnne-Marie C Dingemans
Jan 11, 2020·Recent Patents on Anti-cancer Drug Discovery·Gian L Russo
Oct 12, 2018·Endoscopy International Open·Kazunori NakaokaKentaro Yoshioka
Sep 22, 2017·World Journal of Gastroenterology : WJG·Guido GiordanoMario Rosario D'Andrea
Dec 14, 2018·Annals of Surgical Oncology·Hiroshi KuraharaShoji Natsugoe
Dec 16, 2017·Abdominal Radiology·Vinit BaliyanAvinash Kambadakone
Sep 10, 2020·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Hyungjin Rhee, Mi Suk Park
Apr 4, 2021·Journal of Clinical Medicine·Ruth González-GómezAlberto J Schuhmacher
Oct 26, 2016·Bioorganic & Medicinal Chemistry·Yuqi JiangYingjie Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
David GoldsteinBrian Lu
© 2022 Meta ULC. All rights reserved