PMID: 8600084Mar 15, 1996Paper

Possibility of conservative local treatment after combined chemotherapy and preoperative irradiation for locally advanced noninflammatory breast cancer

International Journal of Radiation Oncology, Biology, Physics
E TouboulM Schlienger

Abstract

The aims of this prospective study were to evaluate the outcome and the possibility of breast conservation therapy for patients with locally advanced noninflammatory breast cancer after primary chemotherapy followed by external preoperative irradiation. Between April 1982 and June 1990, 97 patients with locally advanced nonmetastatic and noninflammatory breast cancer were treated. The median follow-up was 93 months from the beginning of treatment. The induction treatment consisted of four courses of chemotherapy (doxorubicin, vincristine, cyclophosphamide, 5-fluorouracil) followed by preoperative irradiation (45 Gy to the breast and nodal areas). A fifth course of chemotherapy was given after irradiation therapy. Three different loco-regional approaches were proposed, depending on the tumoral response. In 37 patients (38%) with residual tumor larger than 3 cm in diameter or located behind the nipple or with bifocal tumors, mastectomy and axillary dissection were performed. Sixty other patients (62%) benefited from conservative treatment: 33 patients (34%) achieved complete remission and no surgery was done but additional radiation boost was given to the initial tumor bed; 27 patients (28%) who had a residual mass less than or e...Continue Reading

References

Feb 1, 1979·International Journal of Radiation Oncology, Biology, Physics·J R HarrisS Hellman
Jan 1, 1978·Cancer Chemotherapy and Pharmacology·M De LenaG Bonadonna
Jan 1, 1978·Acta Radiologica: Oncology, Radiation, Physics, Biology·B PierquinD Ash
Nov 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E TouboulR A Guerin
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L J PierceK H Cowan
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M SchollP Pouillart
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·M V GrahamB Fineberg
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·E A StromM J Oswald
Oct 3, 1990·Journal of the National Cancer Institute·G BonadonnaF Rilke
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·D P DermanW R Bezwoda
Sep 15, 1987·Cancer·T SheldonJ R Harris
Oct 1, 1985·International Journal of Radiation Oncology, Biology, Physics·C Schaake-KoningE Engelsman
Mar 1, 1983·Cancer·G N HortobagyiF Schell
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B PierquinS Hannoun
Jan 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J BedwinekB Fineberg
Mar 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RubensJ L Hayward
Jan 1, 1981·Cancer·A B MillerA Winkler
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M SchollP Beuzeboc
Mar 1, 1994·International Journal of Radiation Oncology, Biology, Physics·V AhernJ Boyages

❮ Previous
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Citations

May 1, 1997·Seminars in Surgical Oncology·J R White, J F Wilson
Jul 28, 2001·International Journal of Cancer. Journal International Du Cancer·E CalitchiJ P Le Bourgeois
Jun 12, 2002·Current Treatment Options in Oncology·W M Sikov
Mar 15, 1996·International Journal of Radiation Oncology, Biology, Physics·L J Pierce
Jun 26, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D LerougeJ Blondon
Nov 26, 1999·The Surgical Clinics of North America·A G Taghian, S N Powell
Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·F FerrerN Daly-Schveitzer
Nov 7, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K S AsgeirssonR D Macmillan
Jun 8, 2000·The Australian and New Zealand Journal of Surgery·T L Edwards
May 12, 2001·The Breast Journal·Robert W. Carlson, Anne M. Favret
Oct 1, 2013·BioMed Research International·Ciprian ChiraAlain Fourquet
Jun 3, 2014·Critical Reviews in Oncology/hematology·Orit Kaidar-PersonUNKNOWN AROME
Jan 15, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Mustafa EmirogluCengiz Aydın
Mar 10, 2016·Breast Cancer Research : BCR·Raquel F D van la Parra, Henry M Kuerer
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Viswanathan ShantaRamachandran Radhika
Mar 19, 2013·ANZ Journal of Surgery·Patrick TansleyDamien Grinsell
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Delphine LerougeJean Blondon
Nov 27, 2001·American Journal of Surgery·S E Singletary
Aug 9, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Marc A BolletUNKNOWN Institut Curie Breast Cancer Study Group
Jul 8, 2014·The Breast : Official Journal of the European Society of Mastology·Luigia NardoneVincenzo Valentini
Feb 11, 2015·Nature Reviews. Clinical Oncology·Konstantinos TryfonidisFatima Cardoso
May 2, 2017·Plastic and Reconstructive Surgery. Global Open·Pablo A BaltodanoGedge D Rosson
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K M McMasters, K K Hunt
Oct 5, 2018·Radiation Oncology·Miljana TanićRadmila Janković
Jul 1, 1997·Journal of Surgical Oncology·B Erickson, J F Wilson
Sep 18, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R RouzierE Bourstyn

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