Possibility of using laser spectroscopy for the intraoperative detection of nonfluorescing brain tumors and the boundaries of brain tumor infiltrates. Technical note

Journal of Neurosurgery
Satoshi UtsukiKiyotaka Fujii

Abstract

The response of nonfluorescing infiltrating tumors that had been exposed to 5-aminolevulinic acid and irradiated using a laser at a wavelength of 405 nm was analyzed intraoperatively using spectroscopy. Histological analyses demonstrated that neoplastic cells were present in the tissue region that displayed a peak at 636 nm, whereas no neoplastic cells were present in the region that exhibited only the excitation light peak. The authors conclude that the intraoperative use of laser spectroscopy can allow the diagnosis of infiltrating tumor and the detection of boundaries of the infiltrate when standard fluorescence techniques fail.

References

Mar 1, 1992·British Journal of Cancer·M M el-SharabasyS A Salim
Jun 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J C KennedyD C Pross
May 3, 2001·Journal of Photochemistry and Photobiology. B, Biology·K SmetanaZ Hrkal

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Citations

Aug 22, 2013·Journal of Photochemistry and Photobiology. B, Biology·Chunlei WangShiguang Zhao
Aug 1, 2006·Photomedicine and Laser Surgery
Jun 13, 2012·Annals of Surgical Oncology·Shi-Guang ZhaoNikolai G Rainov
Oct 16, 2008·The Keio Journal of Medicine·Masahiro Toda
Jun 2, 2009·Journal of Neurosurgery·Satoshi UtsukiKiyotaka Fujii
Feb 1, 2011·Journal of Neurosurgery·Chul-Kee Park
Oct 20, 2006·Journal of Neurosurgery. Spine·Satoru ShimizuKimihiko Mii
Feb 4, 2014·Neurosurgical Focus·Serge MarbacherJavier Fandino
Jan 28, 2016·Neurosurgical Review·Nicholas FerraroRicardo J Komotar
Mar 2, 2016·Neurosurgical Focus·Pablo A ValdésAlexandra Golby
Jul 31, 2010·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Brian W PogueKeith D Paulsen
May 2, 2006·The Lancet Oncology·Fred G Barker, Susan M Chang
Apr 15, 2014·ISRN Surgery·Johnathan E LawrenceRobert J Winn
Nov 15, 2016·Photodiagnosis and Photodynamic Therapy·Takeshi YoneyamaMitsutoshi Nakada
Feb 26, 2008·Neurologia Medico-chirurgica·Satoshi UtsukiKiyotaka Fujii
Jun 28, 2019·Frontiers in Surgery·Pablo A ValdesAlexandra J Golby
Nov 4, 2015·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A PotapovA P Chumakova
May 26, 2018·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A A PotapovV B Loshchenov
Aug 12, 2018·Journal of Neuro-oncology·Muhammad Omar Chohan, Mitchel S Berger
Dec 17, 2018·Journal of Neuro-oncology·Linpeng WeiJonathan T C Liu
Jul 19, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ronald M Juarez-ChambiJavier A Jo
Jul 6, 2021·Frontiers in Neurology·Alexander J SchupperConstantinos G Hadjipanayis
Aug 17, 2021·Frontiers in Oncology·Barbara KieselGeorg Widhalm

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