Possible activation of the renin-angiotensin system in the feto-placental unit in preeclampsia

The Journal of Clinical Endocrinology and Metabolism
Mitsuaki ItoS Mizutani

Abstract

The purpose of this study was to elucidate the mechanisms underlying the regulation of feto-placental circulation mediated by the renin-angiotensin system under preeclamptic conditions. We measured angiotensin-converting enzyme (ACE) activity, protein expression, and mRNA expression in uncomplicated and preeclamptic placentas and examined the localization of ACE. In addition, ACE activity and mRNA expression in human umbilical venous endothelial cells (HUVECs) under hypoxic conditions were analyzed. ACE activity, protein expression, and mRNA expression in placental tissues from preeclampsia were all significantly higher than those from uncomplicated pregnancies. ACE activity in vessel fractions was extensively higher than that in trophoblast-rich or macrophage-rich fractions. Additionally, ACE activity in HUVECs was significantly higher than that in human arterial endothelial cells, and ACE mRNA was primarily localized to venous endothelial cells of stem villous in placentas. Furthermore, hypoxic condition induced both ACE activity and mRNA expression in HUVECs. These results suggested that venous endothelial cells within placental stem villous tissues and umbilicus play an important role in the regulation of the feto-placental...Continue Reading

References

Mar 12, 1976·Science·P R CaldwellR L Soffer
May 1, 1977·Clinical Science and Molecular Medicine·F Broughton Pipkin, E M Symonds
Feb 1, 1991·British Journal of Obstetrics and Gynaecology·M HanssensF A van Assche
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F SoubrierP Corvol
Apr 29, 1985·Life Sciences·P A Velletri
Nov 1, 1985·Placenta·H TairaY Tomoda
Aug 1, 1987·American Journal of Obstetrics and Gynecology·H S BrarW A Hsueh
Oct 1, 1967·American Journal of Obstetrics and Gynecology·Z M MassaniD Raimondi
Feb 1, 1981·Circulation Research·H S Iwamoto, A M Rudolph
Jul 1, 1983·Neuroendocrinology·R DefendiniE G Erdös
Jan 1, 1983·Clinical and Experimental Hypertension. Part B, Hypertension in Pregnancy·L J BeilinI Rouse
Jan 1, 1995·Methods in Enzymology·P CorvolF Soubrier
Jan 1, 1995·Reproduction, Fertility, and Development·S MizutaniY Tomoda
Aug 1, 1996·Canadian Journal of Physiology and Pharmacology·E R LumbersJ H Burrell
Feb 6, 1998·Proceedings of the Society for Experimental Biology and Medicine·B BonetR H Knopp
Oct 17, 1998·Hypertension·T MorganK Ward
May 1, 2001·Archives of Gynecology and Obstetrics·M FaxénK R Kublickiene

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Citations

Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Lauren Anton, K Bridget Brosnihan
Mar 21, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Wanda NowakRodolfo Pedro Rothlin
Mar 1, 2006·Expert Opinion on Biological Therapy·Kazuhiko InoFumitaka Kikkawa
May 20, 2009·Journal of Cellular Physiology·Yali XiongOssie Geifman-Holtzman
Jun 22, 2012·Journal of Cellular Physiology·Yali XiongOssie Geifman-Holtzman
May 17, 2005·Biochimica Et Biophysica Acta·Atsuo Itakura, Shigehiko Mizutani
Sep 21, 2010·Biochimica Et Biophysica Acta·Mohammad N UddinJules B Puschett
Dec 4, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Saunders LinMohammad N Uddin
Apr 3, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E P VellosoR A S Santos
Dec 14, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Eiki NakamuraTokitsugi Hayashi
Aug 10, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Lukas SchwentnerChristine Wulff
May 5, 2006·Current Hypertension Reports·Dinesh M Shah
Feb 7, 2019·Molecular Human Reproduction·Anya L ArthursKirsty G Pringle
Apr 6, 2019·Current Pharmaceutical Design·Emilie HitzerdA H Jan Danser
Jul 18, 2020·American Journal of Reproductive Immunology : AJRI·Sonam VermaIndira U Mysorekar
Aug 31, 2020·Hypertension·Ellen MenkhorstEva Dimitriadis
Nov 30, 2004·Clinical and Experimental Pharmacology & Physiology·A C ResendeR Soares de Moura
Jul 16, 2014·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O P Petrushova, N I Mikuliak
Jan 5, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ramalingam UmaDeirdre J Murphy
Apr 14, 2021·Current Hypertension Reports·Tashlen AbelThajasvarie Naicker
Oct 21, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sonia TamannaKirsty G Pringle

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