Possible anti-Parkinson properties of N-(alpha-linolenoyl) tyrosine: a new molecule

Pharmacology, Biochemistry, and Behavior
Shlomo Yehuda

Abstract

Tyrosine is unable to cross the blood-brain barrier and is therefore unable to improve the status of brain dopamine (DA) and to provide relief for patients with Parkinson's disease (PD) or other DA-insufficient disorders. We report the creation of an amide bond molecule [N-(alpha-linolenoyl)tyrosine (NLT)] that combines tyrosine with a fatty acid mixture. NLT significantly improves the rotational behavior of rats [following unilateral striatal lesions (as a model for Parkinson's)] and overcomes the exaggerated eye-blinking induced by a potent DA-depleting agent (as a model for essential blepharospasm). These results are supported by the finding that NLT's mode of action, in striatum, is the same as the mode of action of D-amphetamine. They both induce an increase in the DA level, DA turnover and release.

References

Mar 11, 1998·Peptides·S YehudaD I Mostofsky
Apr 16, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A G RiedlC D Marsden
Jul 8, 1998·Neuroscience Letters·M C Sañudo-PeñaJ M Walker
Sep 28, 1998·Archives of Dermatological Research·H AndoM Ichihashi
Feb 13, 1999·European Journal of Pharmacology·S YehudaD I Mostofsky
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K A YoudimJ A Joseph
Dec 7, 2000·Chemistry and Physics of Lipids·N UedaD G Deutsch
Dec 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R J BaldessariniM O Bradley

❮ Previous
Next ❯

Citations

Dec 25, 2002·European Journal of Pharmacology·Werner J GeldenhuysSarel F Malan
Jun 13, 2015·Critical Reviews in Food Science and Nutrition·Shlomo Yehuda, Sharon Rabinovitz
Apr 7, 2007·Bulletin of Experimental Biology and Medicine·M Yu BobrovV V Bezuglov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

© 2022 Meta ULC. All rights reserved