Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population

BMC Medical Genetics
Godwill Azeh EngwaBenjamin Ewa Ubi

Abstract

The association between ABCC8 gene C49620T polymorphism and type 2 diabetes (T2D) in populations of diverse ethnic backgrounds has been reported. However, such occurrence in an African population is yet to be established. This case-control study involving 73 T2D and 75 non-diabetic (ND) patients investigated the occurrence of this polymorphism among T2D patients in Nigeria and assessed its relationship with body lipids of patients. Demographic and clinical characteristics of patients were collected and lipid profile indices including total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL) were assayed. Restriction fragment length polymorphism-PCR (RFLP-PCR) was employed to genotype the ABCC8-C49620T polymorphism using PstI restriction enzyme. This study revealed significantly (p < 0.05) higher prevalence of the T allele of the ABCC8 gene in T2D patients (33.1%) compared to ND patients (28.0%). The mutant TT genotype was also higher than the CC and CT genotypes in T2D patients compared to ND patients but did not show any significant risk (p>0.05) of T2D for the unadjusted codominant, dominant and recessive models. Following age adjustment, the mutant genotypes (CT and TT) showe...Continue Reading

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Citations

Dec 21, 2018·Omics : a Journal of Integrative Biology·Jean Jacques NoubiapAmbroise Wonkam
Jul 21, 2020·Journal of Diabetes Research·Evans Adu AsamoahEnoch Odame Anto
May 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Cheng LiuYan Shen
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Mohammad Bagher SadeghiSaman Sargazi

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Methods Mentioned

BETA
genotyping
PCR
restriction digest

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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