Possible association of cytotoxic T-lymphocyte antigen 4 gene promoter single nucleotide polymorphism with acute rejection of allogeneic kidney transplant

Transplantation Proceedings
A WiśniewskiP Kuśnierczyk

Abstract

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) molecule is an important inhibitor of T-lymphocyte response. Polymorphisms in the CTLA-4 gene have been described to be associated with numerous autoimmune diseases. However, similar studies in solid organ transplantation have been scarce. Therefore, we examined the distribution of three single nucleotide dimorphisms, namely, -1147T/C, -318C/T, and +49A/G, in two groups of allogeneic kidney graft recipients: (1) those with at least one acute rejection episode ("rejectors"; n = 38) and (2) those with no signs of acute rejection ("nonrejectors"; n = 53). Allele frequencies in both groups of patients were similar in two positions, -1147T/C and +49A/G. However, rejectors showed slight differences from nonrejectors for allele and genotype frequencies in position -318. The -318T allele was two times less frequent among rejectors than nonrejectors, a difference that was close to statistical significance (P = .039; P corrected = .0583), and may reach it when greater numbers of patients are tested.

References

Mar 19, 1999·Tissue Antigens·H F HarboA Spurkland
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Sep 24, 2004·Transplant Immunology·Raffaello Cortesini, Nicole Suciu-Foca

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Citations

Dec 10, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Maneesh Kumar MisraSuraksha Agrawal
Oct 14, 2010·Transplant Immunology·Hak-Jae KimJoo-Ho Chung
Nov 19, 2009·Cell Transplantation·Jun SuzukiZhibin Chen
Apr 1, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jui WuYa-Chien Yang
Jun 22, 2021·Frontiers in Immunology·Jose Luis SantiagoAna Isabel Sánchez-Fructuoso

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