PMID: 9185079Apr 1, 1997Paper

Possible association of infertility with sperm-specific abnormality of CD46

Journal of Reproductive Immunology
M KitamuraT Seya

Abstract

Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with sperm-egg interaction. These three patients expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific abnormalities in these proteins thus parallel male infertility, suggesting a new category of infertility, probably due to aberrations in the molecules related to sperm-egg interaction.

References

Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D J AndersonR M Jack
Jan 1, 1993·Molecular Reproduction and Development·F CervoniB Rossi

❮ Previous
Next ❯

Citations

Oct 4, 2005·Springer Seminars in Immunopathology·M Kathryn LiszewskiJohn P Atkinson
Oct 15, 2013·The International Journal of Biochemistry & Cell Biology·Hidekazu YamamotoClaudia Kemper
Jun 26, 2001·Clinical and Experimental Immunology·C KemperJ P Atkinson
Sep 5, 2006·Journal of Reproductive Immunology·Masashi MizunoB Paul Morgan
Jul 19, 2005·Molecular Immunology·Claire L HarrisB Paul Morgan
Apr 26, 2005·The Journal of Clinical Investigation·Rebecca C Riley-VargasJohn P Atkinson
Aug 25, 2004·Trends in Immunology·Rebecca C Riley-VargasJohn P Atkinson
Jul 24, 2014·International Journal of Molecular Sciences·George AnifandisIoannis Messinis
Aug 29, 2000·The Journal of Biological Chemistry·M K LiszewskiJ P Atkinson
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rebecca C RileyJohn P Atkinson
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G WangJ P Atkinson
Jul 12, 2002·Molecular Reproduction and Development·Rebecca C RileyJohn P Atkinson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.