Possible association of nicastrin polymorphisms and Alzheimer disease in the Finnish population

Neurology
Seppo HelisalmiChristine Van Broeckhoven

Abstract

The authors previously reported that genetic variation in the gene coding for nicastrin (NCSTN) modified risk for familial early-onset Alzheimer disease (AD) in a Dutch population-based sample. Risk was highest in patients without an APOE epsilon4 allele. Here, they evaluated if NCSTN polymorphisms increased risk of AD in the eastern Finnish population. A significant difference in one haplotype was observed in AD patients without the APOE epsilon4 allele.

Citations

Oct 21, 2009·The European Journal of Neuroscience·Li ZhongLei Qing-feng
Mar 25, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Elizabeth E MarchaniEllen M Wijsman
May 17, 2005·Brain Research. Molecular Brain Research·Annamaria ConfaloniGianluigi Forloni
Mar 13, 2012·Neurobiology of Aging·Gillian HamiltonRichard Wade-Martins
Oct 19, 2017·Genes, Brain, and Behavior·E E BlueE M Wijsman

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