PMID: 3768693Sep 24, 1986Paper

Possible association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following brain injury in situ

Brain Research
Y TakamiyaY Tsukada

Abstract

The association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following injury was investigated by using a specific antagonist of PDGF, Trapidil. The cerebral cortex of 4-week-old male rats was unilaterally injured with a 22-gauge needle. Immunohistochemical staining with antiserum to glial fibrillary acidic protein revealed that reactive astrocytes had increased in number around the wound by 2 days following the injury and had spread to the ipsilateral areas distant from the wound by 3 days. The appearance of reactive astrocytes in areas distant from the wound was dramatically suppressed by the administration of Trapidil. This finding indicates that PDGF might play a role in gliosis following injury.

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Citations

Apr 24, 1991·Brain Research. Developmental Brain Research·K AbnetS B Dunnett
Jan 7, 1998·Trends in Neurosciences·J L RidetF H Gage
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