Possible benefits of tomato juice consumption: a pilot study on irradiated human lymphocytes from healthy donors

Nutrition Journal
Ayumi NakamuraSiamak Haghdoost

Abstract

Reactive oxygen species (ROS) mediate much of the DNA damage caused by ionizing radiation. Among carotenoids, lycopene and β-carotene, present in tomato juice, are known to be strong radical scavengers. The aim of the study was to investigate the effect of tomato juice intake on the levels of DNA damage and oxidative stress in human whole blood induced by in vitro exposure to X-rays. Ten healthy adults were asked to drink 190 g of tomato juice, containing 17 mg lycopene and 0.25 mg β-carotene, per day for 3 weeks and then refrain from drinking it for 3 weeks. Peripheral whole blood samples were collected before and after the intake period of tomato juice and after the washout period. The blood samples were exposed in vitro to X-ray doses of 0, 0.1, 0.5, and 2 Gy. Cytogenetic damage was measured using the cytokinesis-block micronucleus (CBMN) assay and the dicentrics (DIC) assay. The level of oxidative stress was determined using serum 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxo-dG) and plasma reactive oxygen metabolite-derived compounds (d-ROMs). The concentration of carotenoids in plasma was measured at the three time points. The levels of 8-oxo-dG tended to decrease during the intake period and increase during the washout peri...Continue Reading

References

Sep 30, 1991·The American Journal of Medicine·H Sies
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Apr 1, 1972·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R Roots, S Okada
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
Nov 23, 2000·Nature·T Finkel, N J Holbrook
Dec 19, 2001·Archives of Biochemistry and Biophysics·H R MatosM H Medeiros
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Dec 15, 2004·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·A Venket Rao
Mar 15, 2005·Free Radical Research·Siamak HaghdoostMats Harms-Ringdahl
Jul 26, 2006·Free Radical Biology & Medicine·Siamak HaghdoostMats Harms-Ringdahl
Dec 14, 2006·Gerontology·Bulbul Chakravarti, Deb N Chakravarti
Mar 14, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C ScolasticiD M F Salvadori
Dec 14, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·C ScolasticiD M F Salvadori
Feb 23, 2008·Advances in Experimental Medicine and Biology·Paul OkunieffLurong Zhang
Jan 14, 2009·Radiation Research·Traimate Sangsuwan, Siamak Haghdoost
Dec 2, 2010·European Journal of Clinical Nutrition·D QuilliotO Ziegler
Mar 20, 2012·International Journal of Hygiene and Environmental Health·Shigeo IshikawaAkira Fukao
Apr 25, 2012·Radiation and Environmental Biophysics·Elina StaafAndrzej Wojcik
May 4, 2012·Nutrition Journal·Mats Harms-RingdahlSiamak Haghdoost
Jan 31, 2014·Science Translational Medicine·Volkan I SayinMartin O Bergo
Feb 26, 2016·Journal of Korean Medical Science·Kyung-Hyun Do

❮ Previous
Next ❯

Citations

Aug 17, 2020·Metabolites·Merriline M SatyamitraAndrea L DiCarlo
Jun 8, 2018·Frontiers in Pharmacology·Ioana MozosAtanas G Atanasov
May 8, 2020·Oxidative Medicine and Cellular Longevity·Ali Pour Khavari, Siamak Haghdoost
Jul 24, 2021·Environmental and Molecular Mutagenesis·Paulo Roberto D'Auria Vieira de GodoySiamak Haghdoost

❮ Previous
Next ❯

Methods Mentioned

BETA
chromosomal aberrations
X-ray
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Statcel
Excel
Metafer

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.