Possible Biomarkers for the Early Detection of HIV-associated Heart Diseases: A Proteomics and Bioinformatics Prediction

Computational and Structural Biotechnology Journal
Suraiya RasheedJasper S Yan

Abstract

The frequency of cardiovascular disorders is increasing in HIV-infected individuals despite a significant reduction in the viral load by antiretroviral therapies (ART). Since the CD4 + T-cells are responsible for the viral load as well as immunological responses, we hypothesized that chronic HIV-infection of T-cells produces novel proteins/enzymes that cause cardiac dysfunctions. To identify specific factors that might cause cardiac disorders without the influence of numerous cofactors produced by other pathogenic microorganisms that co-inhabit most HIV-infected individuals, we analyzed genome-wide proteomes of a CD4 + T-cell line at different stages of HIV replication and cell growth over > 6 months. Subtractive analyses of several hundred differentially regulated proteins from HIV-infected and uninfected counterpart cells and comparisons with proteins expressed from the same cells after treating with the antiviral drug Zidovudine/AZT and inhibiting virus replication, identified a well-coordinated network of 12 soluble/diffusible proteins in HIV-infected cells. Functional categorization, bioinformatics and statistical analyses of each protein predicted that the expression of cardiac-specific Ca2 + kinase together with multiple...Continue Reading

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Citations

May 13, 2018·Current HIV/AIDS Reports·Kaku So-Armah, Matthew S Freiberg

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Ingenuity Pathway Analysis ( IPA )
PDQuest
Expasy
UniProt
Ingenuity Pathway Analysis ( IPA ) Systems
BioRad
Global Functional Analysis

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