Possible bone-preserving capacity of high-dose intramuscular depot estrogen as compared to orchidectomy in the treatment of patients with prostatic carcinoma

The Prostate
K CarlströmA Pousette

Abstract

Treatment of prostatic disease with GnRH agonists or by orchidectomy affects bone mass negatively. Estrogen treatment has beneficial effects on bone mass in women and might hypothetically have a bone preserving capacity also in patients with prostatic cancer. We followed serum markers for bone and collagen metabolism and sex steroids for 18 months in patients with prostatic cancer treated by orchidectomy (N = 13) or by single-drug parenteral polyestradiol phosphate (240 mg intramuscularly every second week for the first two months, and then every fourth week; N = 17). Total and free testosterone reached castration levels within 1.5 months of estrogen treatment. Four patients developing progressive disease and/or signs of metastasis were excluded from the analysis. In the remaining patients, serum osteocalcin, procollagen IIIP (PIIINP), procollagen (PICP), and the crosslinked carboxyterminal telopeptide of type I collagen (ICTP) increased significantly over time following orchidectomy (N = 11). Serum osteocalcin and PICP decreased significantly over time during estrogen treatment (N = 15). Treatment values of all four markers were significantly lower in estrogen-treated than in orchidectomized patients. The changes in serum bone...Continue Reading

References

Mar 1, 1990·British Journal of Urology·P HenrikssonK Carlström
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Feb 1, 1986·Endocrine Reviews·F LabrieG Monfette
Aug 1, 1995·Calcified Tissue International·S ErikssonK Carlström
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Feb 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E F EriksenJ Risteli

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Citations

Apr 21, 1999·Clinical Endocrinology·S ReutrakulR Rajatanavin
Mar 1, 2006·Expert Opinion on Investigational Drugs·Samir S TanejaKaren A Veverka
Apr 16, 2015·International Journal of Endocrinology·Vincenzo RochiraCesare Carani
Feb 25, 2000·Human Reproduction·D J HandelsmanA J Conway
Jul 28, 2004·Prostate Cancer and Prostatic Diseases·D Kirk
Jul 17, 1999·British Journal of Cancer·C J Tyrrell
Nov 1, 2005·Scandinavian Journal of Urology and Nephrology·Mirtha GrandeAke Pousette

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