Possible calcium channel modulating activity of iloprost in rabbit isolated vascular segments.

General Pharmacology
E Demirel, R K Türker

Abstract

1. Iloprost produced a concentration-dependent decrease in the contractile responses to K+ and NA in CoeA and SMA strips without altering the responses in RA, MPA, CaA and ThA. 2. Nifedipine and verapamil also inhibited the contractile responses to NA and K+ in CoeA and SMA rings in a concentration dependent manner. 3. Removal of endothelium did not alter the inhibitory effects of iloprost and Ca2+ channel blockers in the investigated arterial segments. 4. In Ca2+ free and high K+ medium both iloprost and Ca2+ channel blockers potentially inhibited the contractile effect of external Ca2+. 5. Iloprost at lowest concentration which is not influence the contractile response of K+ can potentiate the inhibitory effect of nifedipine in CoeA and SMA rings without altering its inhibitory effect on NA responses. 6. These results suggest that iloprost may modulate Ca2+ entry into the cell probably by acting through the potential-operated Ca2+ channels in CoeA and SMA. These results also indicate that Ca2+ channels are heterogenously functioned in various vascular segments of rabbit.

References

Oct 1, 1977·European Journal of Pharmacology·G J DustingJ R Vane
Jun 1, 1978·Prostaglandins·K PomerantzP Ramwell
Apr 1, 1979·Prostaglandins·C E Chapleau, R P White
Dec 1, 1987·European Journal of Pharmacology·J M BoeynaemsN Galand
Jan 15, 1986·Biochemical Pharmacology·V J Van de VeldeA G Herman
Dec 1, 1986·British Journal of Pharmacology·P Hadházy, K Magyar

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Citations

Mar 1, 1993·General Pharmacology·N EgemenA Unlü
Mar 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S PalaogluR K Turker

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