PMID: 45482Nov 1, 1977

Possible changes in striatal and limbic cholinergic systems in schizophrenia

Archives of General Psychiatry
P L McGeer, E G McGeer


Enzymes concerned with neurotransmitter metabolism were measured postmortem in 50 regions from the brains of 11 chronic schizophrenics, 2 patients with senile dementia, 1 depressive, and 18 controls. Enzymes studied were tyrosine hydroxylase, dopa decarboxylase, glutamic decarboxylase, choline acetyltransferase (CAT), and acetylcholinesterase. The schizophrenic group had high CAT activities in the hippocampus, caudate, putamen, and nucleus accumbens; the other patients from the same hospital did not. A compensatory response to long- or short-term drug usage is considered, but correlations are hard to establish in the group studied. An alternative hypothesis proposes that the high levels are a compensatory response to defective cholinergic receptors in the affected areas. On this hypothesis, and by analogy with chorea, dopaminergic antagonists would act in schizophrenia by helping to reestablish cholinergic-dopaminergic balance.


Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S L DeweyA P Wolf
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie K JonesMichael Bubser
Jul 27, 2001·Journal of Chemical Neuroanatomy·Thomas M Hyde, J M Crook
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frank P BymasterDavid L Mckinzie
May 1, 1991·Psychiatry Research·C N KarsonR D Skinner
Jun 1, 1988·Biological Psychiatry·S P MahadikS E Karpiak
May 1, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yukihiko ShirayamaRyuzou Kawahara
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·D MancamaM J Arranz
Oct 30, 2008·Journal of Neurochemistry·Elizabeth Scarr, B Dean
Jan 14, 1982·Brain Research·P T WongE G McGeer
Aug 24, 2011·Nordic Journal of Psychiatry·Maurizio Coppola, Raffaella Mondola
Dec 18, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·François LaplanteRon M Sullivan
Nov 7, 2014·Frontiers in Synaptic Neuroscience·Sean Austin O LimDaniel S McGehee
Aug 23, 2000·The Australian and New Zealand Journal of Psychiatry·B Dean
Jul 1, 1979·Acta Psychiatrica Scandinavica·B WinbladB E Roos
Sep 1, 1979·The Journal of Pharmacy and Pharmacology·J L Waddington, A J Cross

Related Concepts

Limbic System
Enzymes, antithrombotic
Acute Cholinergic Dysautonomia
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