Possible contribution of serum activin A and IGF-1 in the development of hepatocellular carcinoma in Egyptian patients suffering from combined hepatitis C virus infection and hepatic schistosomiasis

Clinical Biochemistry
Mohamed Yousry ElsammakMona M Abaza

Abstract

The present study evaluated the role of activin A, insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) in Egyptian patients suffering from combined hepatitis C virus (HCV) infection and hepatic schistosomiasis. Four groups were included in the present study. Group I: 30 healthy subjects were included as controls; Group II (HCV): 30 patients with chronic liver disease due to HCV infection without evidence of schistosomiasis; Group III (SHF + HCV): 30 patients with combined disease, chronic schistosomal hepatic fibrosis (SHF) and chronic hepatitis C infection; Group IV (HCC): 30 patients with hepatocellular carcinoma associated with chronic hepatitis C virus and schistosomal infection. Patients with HCV, HCV + SHF and those with HCC had a significantly higher serum activin A compared with the control group (P < 0.001). Serum activin A level (mean +/- SD) was 5.7 +/- 2.76, 10.59 +/- 3.59, 15.39 +/- 4.61 and 19.93 +/- 5.43 ng/mL in controls, HCV patients, HCV + SHF patients and HCC patients, respectively. Serum IGF-1 was significantly lower in HCV patients, HCV + SHF patients and HCC patients compared to the control group (P < 0.001). Serum IGF-1 was 121.7 +/- 73.4, 76.7 +/- 23.5, 35.7 +/...Continue Reading

References

Sep 1, 1987·The Journal of Cell Biology·M B SpornB de Crombrugghe
Sep 1, 1993·The Journal of Clinical Investigation·H YasudaI Kojima
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·S O StuverD Trichopoulos
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K MatsuzakiK Inoue
May 29, 2001·Molecular Pathology : MP·J G ScharfG Ramadori
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Axel M GressnerSteven Dooley
Oct 16, 2002·The Journal of Endocrinology·S Mohan, D J Baylink
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter C GrayWylie Vale
Jun 14, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Antonio PicardiAntonella Afeltra
Jul 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Mark A FebbraioBente Klarlund Pedersen
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J-G Scharf, T Braulke
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle Dupont, Martin Holzenberger
Apr 22, 2005·Scandinavian Journal of Gastroenterology·J F TsaiC Y Dai
Jul 1, 2005·Parasite Immunology·A FaridG T Strickland
Jul 16, 2005·Journal of Hepatology·Naglaa ArafaArnaud Fontanet

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Citations

Sep 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmed O KasebJames L Abbruzzese
Jul 16, 2010·PLoS Computational Biology·Tetsuya ShiraishiHiroaki Kitano
Aug 1, 2007·Biomarkers in Medicine·Jeng-Eing JengJung-Fa Tsai
Jan 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Menka M SanghviAlan Fenwick
Feb 7, 2012·European Journal of Clinical Investigation·Argyro VoumvourakiElias Kouroumalis
Sep 26, 2006·Mutation Research·Chantal Rodgarkia-DaraMichael Grusch
Nov 13, 2007·Digestive Diseases and Sciences·Manuela G NeumanGiuliano Ramadori
Aug 19, 2010·British Journal of Cancer·J M MajorD Albanes
Oct 31, 2009·World Journal of Hepatology·Emanuel KreidlMichael Grusch

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