Abstract
The present study evaluated the role of activin A, insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) in Egyptian patients suffering from combined hepatitis C virus (HCV) infection and hepatic schistosomiasis. Four groups were included in the present study. Group I: 30 healthy subjects were included as controls; Group II (HCV): 30 patients with chronic liver disease due to HCV infection without evidence of schistosomiasis; Group III (SHF + HCV): 30 patients with combined disease, chronic schistosomal hepatic fibrosis (SHF) and chronic hepatitis C infection; Group IV (HCC): 30 patients with hepatocellular carcinoma associated with chronic hepatitis C virus and schistosomal infection. Patients with HCV, HCV + SHF and those with HCC had a significantly higher serum activin A compared with the control group (P < 0.001). Serum activin A level (mean +/- SD) was 5.7 +/- 2.76, 10.59 +/- 3.59, 15.39 +/- 4.61 and 19.93 +/- 5.43 ng/mL in controls, HCV patients, HCV + SHF patients and HCC patients, respectively. Serum IGF-1 was significantly lower in HCV patients, HCV + SHF patients and HCC patients compared to the control group (P < 0.001). Serum IGF-1 was 121.7 +/- 73.4, 76.7 +/- 23.5, 35.7 +/...Continue Reading
References
Sep 1, 1987·The Journal of Cell Biology·M B SpornB de Crombrugghe
Jun 1, 1986·Gut·K M De Cock
Sep 1, 1993·The Journal of Clinical Investigation·H YasudaI Kojima
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·S O StuverD Trichopoulos
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K MatsuzakiK Inoue
Nov 25, 2000·Alcohol·O NedićR Masnikosa
Apr 25, 2001·Liver·S OrmarsdóttirL Lööf
May 29, 2001·Molecular Pathology : MP·J G ScharfG Ramadori
Feb 15, 2002·Scandinavian Journal of Gastroenterology·M F YuenR D Hughes
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Axel M GressnerSteven Dooley
Oct 16, 2002·The Journal of Endocrinology·S Mohan, D J Baylink
Oct 16, 2002·The Journal of Endocrinology·C Duan
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter C GrayWylie Vale
Jun 14, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Antonio PicardiAntonella Afeltra
Jul 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Mark A FebbraioBente Klarlund Pedersen
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J-G Scharf, T Braulke
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle Dupont, Martin Holzenberger
Jan 11, 2005·Cancer·Raymond T Chung
Jan 13, 2005·Scandinavian Journal of Immunology·I M El-KadyI Waked
Apr 22, 2005·Scandinavian Journal of Gastroenterology·J F TsaiC Y Dai
Jul 1, 2005·Parasite Immunology·A FaridG T Strickland
Jul 16, 2005·Journal of Hepatology·Naglaa ArafaArnaud Fontanet
Citations
Aug 9, 2011·Oncology·Ahmed O KasebJeffrey S Morris
Sep 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmed O KasebJames L Abbruzzese
Jul 16, 2010·PLoS Computational Biology·Tetsuya ShiraishiHiroaki Kitano
Aug 1, 2007·Biomarkers in Medicine·Jeng-Eing JengJung-Fa Tsai
May 7, 2014·Gastroenterology Research and Practice·Bassem RefaatAdnan Alzanbagi
Jan 9, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Menka M SanghviAlan Fenwick
Feb 7, 2012·European Journal of Clinical Investigation·Argyro VoumvourakiElias Kouroumalis
May 21, 2010·Journal of Clinical Laboratory Analysis·Wei-Wen SuShen-Nien Wang
Sep 26, 2006·Mutation Research·Chantal Rodgarkia-DaraMichael Grusch
Jun 14, 2014·Clinical and Experimental Medicine·Bassem RefaatAdnan AlZanbagi
Aug 4, 2015·Mediators of Inflammation·Bassem RefaatNoha Mohammed Al-Qadi
Jun 27, 2015·BMC Research Notes·Bassem RefaatAhmed Mohammed Ashshi
May 15, 2015·Mediators of Inflammation·Bassem RefaatEsam Azhar
Jul 31, 2007·The American Journal of Gastroenterology·Ursula PlöckingerThomas Berg
Nov 13, 2007·Digestive Diseases and Sciences·Manuela G NeumanGiuliano Ramadori
Jul 2, 2009·Yonsei Medical Journal·Chiou-Meei LinZu-Yau Lin
Aug 19, 2010·British Journal of Cancer·J M MajorD Albanes
Feb 2, 2013·British Journal of Cancer·W-P KohJ-M Yuan
Oct 31, 2009·World Journal of Hepatology·Emanuel KreidlMichael Grusch
Oct 4, 2014·World Journal of Gastroenterology : WJG·Yousra A MohamoudLaith J Abu-Raddad
Jun 29, 2012·Oncology Letters·Eiman AleemAsmaa Hela
Feb 20, 2016·Experimental and Therapeutic Medicine·Sheng LiuXuewen Jiang
Sep 9, 2021·Pathogens and Global Health·Hend Ibrahim ShoushaRania Leithy