Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors

Bioorganic & Medicinal Chemistry Letters
Manik PullagurlaRichard A Glennon

Abstract

A graphics model of the human 5-HT6 receptor was constructed and automated docking studies were performed. The model suggests that 5-HT6 antagonist arylsulfonyltryptamines might bind differently than that of the agonist serotonin. Furthermore, the model explains many of the empirical results from our previous structure-affinity studies.

References

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Citations

May 27, 2005·Bioorganic & Medicinal Chemistry·Annalida BediniGilberto Spadoni
Mar 29, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Ramakrishna V S NirogiMukkanti Khagga
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