Possible dual role of decorin in abdominal aortic aneurysm

PloS One
Koshiro UedaKimikazu Hamano

Abstract

Abdominal aortic aneurysm (AAA) is characterized by chronic inflammation, which leads to pathological remodeling of the extracellular matrix. Decorin, a small leucine-rich repeat proteoglycan, has been suggested to regulate inflammation and stabilize the extracellular matrix. Therefore, the present study investigated the role of decorin in the pathogenesis of AAA. Decorin was localized in the aortic adventitia under normal conditions in both mice and humans. AAA was induced in mice using CaCl2 treatment. Initially, decorin protein levels decreased, but as AAA progressed decorin levels increased in all layers. Local administration of exogenous decorin prevented the development of CaCl2-induced AAA. However, decorin was highly expressed in the degenerative lesions of human AAA walls, and this expression positively correlated with matrix metalloproteinase (MMP)-9 expression. In cell culture experiments, the addition of decorin inhibited secretion of MMP-9 in vascular smooth muscle cells, but had the opposite effect in macrophages. The results suggest that decorin plays a dual role in AAA. Adventitial decorin in normal aorta may protect against the development of AAA, but macrophages expressing decorin in AAA walls may facilitate t...Continue Reading

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Citations

Nov 20, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Takasuke HaradaKimikazu Hamano
Jul 28, 2018·Cardiovascular Research·Juliette RaffortZiad Mallat
Jun 20, 2019·Frontiers in Cardiovascular Medicine·Aneesh K RamaswamyJustin S Weinbaum
Aug 5, 2020·International Journal of Molecular Sciences·Koichi YoshimuraKimikazu Hamano
Aug 20, 2021·The International Journal of Biochemistry & Cell Biology·Chien-Jung Lin, Robert P Mecham

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Methods Mentioned

BETA
lavage
protein assay
enzyme-linked immunosorbent assay

Software Mentioned

GraphPad
Prism

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