Possible effects of polychlorinated biphenyls and organochlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution

Journal of Occupational and Environmental Medicine
Pavel LangerIwar Klimes

Abstract

The purpose of this work was to study the effects of high environmental exposure to polychlorinated biphenyls (PCBs) and other organochlorines on the thyroid. Thyroid volume, hypoechogenicity and nodules (by ultrasound), presence of antithyroid peroxidase (anti-TPO) antibodies, and abnormal thyroid-stimulating hormone (TSH) levels in serum (by radioimmunoassay) were examined in 101 adults from the PCB-polluted area in 360 controls. Serum levels of PCBs, hexachlorobenzene, gamma-hexachlorocyclohexane (HCH), p,p'-DDT(1,1,1-trichloro-2,2'-bis(p-chlorophenyl)ethane), and p,p'-DDE(1,1-dichloro-2,2'-bis(p-chlorophenyl)ethene) were measured by high-resolution gas chromatography. Very high levels of PCBs were found in the polluted area (7300 +/- 871 ng/g lipids) compared with controls (2045 +/- 147 ng/g). Positive correlations (P < 0.001) were found between the levels of all organochlorines and their total except for hexachlorocyclohexane (HCH). In the polluted area, the highest thyroid volumes (18.7 +/- 2.32 mL; mean +/- SE) were clustered among 23 subjects (17 males and six females) with PCB levels above 10,000 ng/g (range 10,000-58,667 ng/g). In the remaining 438 subjects the thyroid volume was 14.2 +/- 0.29 mL. These data suggest t...Continue Reading

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Citations

Nov 7, 2007·Environmental Monitoring and Assessment·Ozlem Erdoğrul
Dec 9, 2003·Chemosphere·Marian PavukAnton Kocan
Apr 28, 2004·Hearing Research·Saida HadjabPhilippe Siaud
May 17, 2005·The Science of the Total Environment·John Beard, UNKNOWN Australian Rural Health Research Collaboration
Feb 27, 2008·Thyroid : Official Journal of the American Thyroid Association·Zofia RádikováPavel Langer
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Jun 2, 2005·Environmental Health : a Global Access Science Source·John JarrellHoward Hu
Nov 12, 2015·The Science of the Total Environment·Jingxian WangKarl-Werner Schramm
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Jan 6, 2009·Bioscience Hypotheses·Yawei ZhangTongzhang Zheng
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Jan 30, 2007·Environmental Science & Technology·B GómaraM J González

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