Possible Hepatotoxicity Associated With Daptomycin: A Case Report and Literature Review

Journal of Pharmacy Practice
Yoonsun MoSeth T Housman

Abstract

To report a case of isolated daptomycin-induced acute liver injury without elevations in creatine kinase (CK) levels or kidney dysfunction. A 49-year-old female with a history of pancreatitis, lupus, diabetes, congestive heart failure, hypertension, and chronic pain syndrome presented to the emergency department with alteration in mental status and acute liver failure. The patient had been treated with daptomycin for methicillin-resistant Staphylococcus aureus (MRSA) endocarditis for 3 weeks. After ruling out other possible etiologies, daptomycin was suspected as a cause of acute liver failure. Her liver failure resolved gradually following withdrawal of daptomycin. Although hepatic abnormalities caused by daptomycin are rare, a handful of cases with daptomycin-induced liver injury have been reported in the literature. Of note, in most cases, patients on daptomycin therapy developed liver damage with elevations in CK levels. Our case report suggests possible severe liver injury associated with high-dose and long-term daptomycin treatment in the absence of rhabdomyolysis. Future research is warranted to further investigate the relationship between daptomycin use and liver injury, yet it is reasonable to monitor liver function te...Continue Reading

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Barry H DvorchikRobert D Arbeit
Jun 17, 2004·Journal of Clinical Pharmacology·Barry Dvorchik
Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert D ArbeitUNKNOWN Daptomycin 98-01 and 99-01 Investigators
Mar 4, 2005·The Journal of Antimicrobial Chemotherapy·Kelly EchevarriaJames S Lewis
Jan 18, 2006·The Journal of Antimicrobial Chemotherapy·Amir KazoryI David Weiner
Aug 18, 2006·The New England Journal of Medicine·Vance G FowlerUNKNOWN S. aureus Endocarditis and Bacteremia Study Group
Sep 7, 2007·International Journal of Antimicrobial Agents·Samir J PatelWadi N Suki
Apr 3, 2008·The Annals of Pharmacotherapy·George AbrahamLinda M Spooner
Jun 9, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D A FigueroaS Segal-Maurer
Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine LiuHenry F Chambers
Oct 2, 2013·Antimicrobial Agents and Chemotherapy·Manuela CarugatiUNKNOWN International Collaboration on Endocarditis
May 8, 2014·Scandinavian Journal of Infectious Diseases·S Travis KingRichard W Finley
May 14, 2014·Antimicrobial Agents and Chemotherapy·Nicole BohmT Rogers Kyle

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