Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis

International Journal of Molecular Sciences
Kenichi KumagaiRyuji Suzuki

Abstract

Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailable. We have previously established novel murine models of metal allergy and found accumulation of both metal-specific T cells and natural killer (NK) T cells in the inflamed skin. In our novel models of metal allergy, skin hypersensitivity responses were induced through repeated sensitizations by administration of metal chloride and lipopolysaccharide into the mouse groin followed by metal chloride challenge in the footpad. These models enabled us to investigate the precise mechanisms of the immune responses of metal allergy in the inflamed skin. In this review, we summarize the immune responses in several murine models of metal allergy and describe which antigen-specific responses occur in the inflamed skin during allergic contact dermatitis in terms of the T cell receptor. In addition, we consider the immune regulation of accumulated NK T cells in metal ion-induced allergic contact dermatitis.

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Citations

Jun 11, 2020·International Journal of Molecular Sciences·Hiroaki ShigematsuRyuji Suzuki
Jul 5, 2017·International Journal of Molecular Sciences·Ryota MatsubaraRyuji Suzuki
Jan 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Dana Filatova, Christine Cherpak

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Methods Mentioned

BETA
PCR

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