PMID: 9172019Dec 1, 1996Paper

Possible immunomodulating activities of carotenoids in in vitro cell culture experiments

International Journal of Immunopharmacology
Y Okai, K Higashi-Okai

Abstract

Immunomodulating activities of beta-carotene and carotene-associated carotenoids such as canthaxanthin (beta, beta-carotene-4,4 dione) and astaxanthin (3,3'-dihydroxyl beta, beta-carotene 4,4-dione) were analyzed by in vitro cell culture experiments. (i) beta-Carotene, canthaxanthin and astaxanthin caused significant stimulatory effects on the cell proliferative response of spleen cells and thymocytes from BALB/c mice at the concentrations of 2 x 10(-8) to 10(-7) M, although they showed the activities different from each other. (ii) Astaxanthin exhibited the highest activity on the polyclonal antibody (immunoglobulin M and G) production of murine spleen cells at the concentrations of 2 x 10(-8) to 10(-7) M but beta-carotene did not cause a significant effect at a low concentration (2 x 10(-8) M) although stimulated at a high concentration (2 x 10(-7) M). Canthaxanthin expressed moderate activities at the same concentrations. (iii) All tested carotenoids significantly enhanced the release of interleukin-1 alpha and tumor necrosis factor-alpha from murine peritoneal adherent cells at the concentrations of 2 x 10(-8) to 10(-7) M and the ranks of cytokine-inducing activities were astaxanthin > canthaxanthin > beta-carotene. These r...Continue Reading

References

Jun 6, 1990·Journal of the National Cancer Institute·K Smigel
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Jan 1, 1985·Immunology Letters·Y OkaiU Yamashita
Dec 1, 1988·Mutation Research·H HayatsuT Negishi
Apr 22, 1994·Science·W C Willett

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Citations

Jul 8, 2005·Applied Microbiology and Biotechnology·Prakash Bhosale, Paul S Bernstein
Dec 12, 2012·Applied Microbiology and Biotechnology·Tamás PappCsaba Vágvölgyi
Mar 14, 2000·Veterinary Immunology and Immunopathology·H W KimG A Reinhart
Mar 31, 2000·Trends in Biotechnology·R T Lorenz, G R Cysewski
May 3, 2003·Trends in Biotechnology·Martin GuerinMiguel Olaizola
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·X WangT Wadström
Jan 7, 2005·Biological & Pharmaceutical Bulletin·Ghazi HusseinHiroshi Watanabe
Jan 1, 2010·International Journal of Molecular Sciences·Jeong-Hwan KimYung-Hyun Choi
Dec 7, 2013·Veterinary Research Communications·Soroush GhodratizadehReza Habibian
May 10, 2005·European Journal of Pharmacology·Jeong-Hwan KimHyo-Ihl Chang
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Ivana BaralicSnezana Pejic
Apr 14, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeong Hwan KimYung Hyun Choi
Oct 25, 2013·Journal of Pharmacological Sciences·Tomohiro OtsukaHideaki Hara
Jan 7, 2011·Veterinary Immunology and Immunopathology·Boon P ChewJean Soon Park
Dec 17, 2014·World Journal of Microbiology & Biotechnology·Árpád CserneticsTamás Papp
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Hasina BegumMohamed Shariff
Oct 30, 2016·British Journal of Pharmacology·Alireza MilaniAzam Bolhassani
Oct 1, 2016·Molecular Nutrition & Food Research·Tuba Esatbeyoglu, Gerald Rimbach
Jun 1, 2017·Parasite : Journal De La Société Française De Parasitologie·José María Eloy Contreras-OrtizJuan Carlos Vázquez-Chagoyán
Jul 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yi-Jen PengChih-Chien Wang
Feb 9, 2012·Toxicology and Industrial Health·Hasan TurkezMokhtar I Yousef
Apr 25, 2018·Nutrients·Sergio DavinelliGiovanni Scapagnini
Aug 5, 2000·The Journal of Nutrition·B P ChewG A Reinhart
Aug 5, 2009·Journal of Agricultural and Food Chemistry·Merichel PlazaElena Ibáñez
May 6, 2021·Natural Product Research·Alessio AlesciEugenia Rita Lauriano
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J P Yuan, F Chen

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