Possible Implication of the CA2 Hippocampal Circuit in Social Cognition Deficits Observed in the Neuroligin 3 Knock-Out Mouse, a Non-Syndromic Animal Model of Autism

Frontiers in Psychiatry
Brijesh ModiMarilena Griguoli

Abstract

Autism spectrum disorders (ASDs) comprise a heterogeneous group of neuro-developmental abnormalities with a strong genetic component, characterized by deficits in verbal and non-verbal communication, impaired social interactions, and stereotyped behaviors. In a small percentage of cases, ASDs are associated with alterations of genes involved in synaptic function. Among these, relatively frequent are mutations/deletions of genes encoding for neuroligins (NLGs). NLGs are postsynaptic adhesion molecules that, interacting with their presynaptic partners neurexins, ensure the cross talk between pre- and postsynaptic specializations and synaptic stabilization, a condition needed for maintaining a proper excitatory/inhibitory balance within local neuronal circuits. We have focused on mice lacking NLG3 (NLG3 knock-out mice), animal models of a non-syndromic form of autism, which exhibit deficits in social behavior reminiscent of those found in ASDs. Among different brain areas involved in social cognition, the CA2 region of the hippocampus has recently emerged as a central structure for social memory processing. Here, in vivo recordings from anesthetized animals and ex vivo recordings from hippocampal slices have been used to assess th...Continue Reading

Associated Datasets

Apr 1, 2020·C. MarchettiM. Griguoli

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Citations

Feb 19, 2020·The Journal of General Physiology·Vincent RobertRebecca A Piskorowski
Aug 8, 2020·Nature·Hanna HörnbergPeter Scheiffele
Jan 17, 2020·Development, Growth & Differentiation·Mohammad Badrul AnamKunimasa Ohta
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Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee
Jul 3, 2021·International Journal of Molecular Sciences·Nicholas H HarbinJohn R Hepler

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Methods Mentioned

BETA
genotyping
biopsy
PCR
SGA2

Software Mentioned

MATLAB
WaveClus
Image J
MetaMorph
Ensemble
chronux
Clampex
GraphPad Prism
wave clus
Clampfit

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