Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease

Thyroid : Official Journal of the American Thyroid Association
Susan E HodgeYaron Tomer

Abstract

Graves' disease (GD) is influenced by two major susceptibility loci, HLA-DR3 and thyroglobulin (Tg). Recently we have shown that specific HLA-DR and Tg gene sequences predispose to Graves' disease. Individuals carrying at least one arginine at position 74 of the DRbeta1 chain (denoted the R- genotype) have a significantly increased risk of GD, as do individuals homozygous for the single nucleotide protein (SNP) in exon 33 of the Tg gene (denoted the CC genotype). Therefore, for the current study we hypothesized that these two genes may interact to influence the etiology of GD. To test this hypothesis, we analyzed the genotypes of 185 Caucasian patients with GD and 143 Caucasian controls for both genes. We tested for an interaction effect, that is, is one gene's effect on GD greater when the other gene is also present than when the other gene is absent? A logistic regression analysis yielded an estimate of 4.31 for the interaction term (p = 0.053). Our results may suggest an interaction between the R- and CC variants in conferring susceptibility to GD. These results, if confirmed, may imply that these two variants interact biologically to increase the odds of GD.

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Citations

Apr 2, 2009·Medizinische Klinik·Georg DultzGeorge J Kahaly
Jan 15, 2011·Clinical Reviews in Allergy & Immunology·Deirdre Cocks EschlerYaron Tomer
Mar 30, 2012·Immunologic Research·Alia Hasham, Yaron Tomer
Sep 11, 2007·Thyroid : Official Journal of the American Thyroid Association·Eric M Jacobson, Yaron Tomer
Dec 1, 2007·Thyroid : Official Journal of the American Thyroid Association·Terry F Davies
Dec 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Georg DultzGeorge J Kahaly
Jul 8, 2010·Thyroid : Official Journal of the American Thyroid Association·Yaron Tomer
Mar 26, 2011·Briefings in Functional Genomics·Matthew J Simmonds, Stephen C L Gough
May 29, 2009·Current Opinion in Pediatrics·Rosalind S Brown
Sep 14, 2012·Epilepsia·David A Greenberg, William C L Stewart
Jun 19, 2008·The Journal of Clinical Endocrinology and Metabolism·Yoshiyuki BanYaron Tomer
Jan 15, 2009·The Journal of Clinical Endocrinology and Metabolism·Maria Justina B VillanoYaron Tomer
Jan 28, 2014·Annual Review of Pathology·Yaron Tomer
Jul 16, 2014·International Journal of Molecular Sciences·Ni YanJinan Zhang
Mar 23, 2010·Journal of Autoimmunity·Francesca MenconiYaron Tomer
Mar 25, 2009·Journal of Autoimmunity·Yaron Tomer, Amanda Huber
Jan 8, 2008·Journal of Autoimmunity·Eric M JacobsonYaron Tomer
Aug 4, 2015·Journal of Autoimmunity·Hanna J LeeYaron Tomer
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Jan 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Yu-Ru MaHuai-Dong Song
Mar 27, 2013·Nature Reviews. Endocrinology·Matthew J Simmonds
Apr 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Qian-Yue ZhangHuai-Dong Song
Dec 26, 2015·The Journal of Biological Chemistry·Cheuk Wun LiYaron Tomer
Apr 27, 2013·International Reviews of Immunology·Agata Jabrocka-HybelAlicja Hubalewska-Dydejczyk
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