Possible introgression of the VRTN mutation increasing vertebral number, carcass length and teat number from Chinese pigs into European pigs

Scientific Reports
Jie YangJ Ren

Abstract

Vertnin (VRTN) variants have been associated with the number of thoracic vertebrae in European pigs, but the association has not been evidenced in Chinese indigenous pigs. In this study, we first performed a genome-wide association study in Chinese Erhualian pigs using one VRTN candidate causative mutation and the Illumina Porcine 60K SNP Beadchips. The VRTN mutation is significantly associated with thoracic vertebral number in this population. We further show that the VRTN mutation has pleiotropic and desirable effects on teat number and carcass (body) length across four diverse populations, including Erhualian, White Duroc × Erhualian F2 population, Duroc and Landrace pigs. No association was observed between VRTN genotype and growth and fatness traits in these populations. Therefore, testing for the VRTN mutation in pig breeding schemes would not only increase the number of vertebrae and nipples, but also enlarge body size without undesirable effects on growth and fatness traits, consequently improving pork production. Further, by using whole-genome sequence data, we show that the VRTN mutation was possibly introgressed from Chinese pigs into European pigs. Our results provide another example showing that introgressed Chines...Continue Reading

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Citations

May 12, 2016·Asian-Australasian Journal of Animal Sciences·Jianhong TangNengshui Ding
Aug 5, 2017·Animal Science Journal = Nihon Chikusan Gakkaihō·Jieping HuangChuzhao Lei
May 16, 2019·Journal of Animal Science·Jungjae LeeJun-Mo Kim
Apr 21, 2017·Asian-Australasian Journal of Animal Sciences·Zhifeng ZhangChangyan Tian
Apr 29, 2020·Animals : an Open Access Journal From MDPI·Zengkui LuBohui Yang

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Datasets Mentioned

BETA
SRA096093
ERP001813

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

Primer Premier
GenABEL
doGeno
SAMtools
house Perl scripts
Bowtie2
in
MEGA
doMaf
ANGSD

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