PMID: 11310789Apr 20, 2001Paper

Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes

Pigment Cell Research
H YanaseN Matsuda

Abstract

UV-induced melanogenesis is a well known physiological response of human skin exposed to solar radiation; however, the signaling molecules involved in the stimulation of melanogenesis in melanocytes following UV exposure remain unclear. In this study we induced melanogenesis in vitro in normal human epidermal melanocytes using a single irradiation with UVA at 1 kJ/m2 and examined the potential involvement of mitogen-activated protein kinases (MAPK) as UVA-responsive signaling molecules in those cells. UVA irradiation did not affect the proliferation of melanocytes, but it did increase tyrosinase mRNA expression, which reached a maximum level 4 hr after UVA irradiation. The amount of tyrosinase protein, as quantitated by immunoblotting, was also increased at 24 hr following UVA irradiation. Among the MAPK examined, extracellular signal-related kinase (ERK) 1/2 was phosphorylated within 15 min of UVA irradiation, but no such phosphorylation was observed for c-Jun N-terminal kinases (JNK) or p38. Accordingly, the activity of ERK1/2 was also increased shortly after UVA irradiation. These responses of ERK1/2 to UVA irradiation were markedly inhibited when cells were pre-treated with N-acetyl-L-cysteine, an antioxidant, or with suram...Continue Reading

Citations

Oct 17, 2003·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Nov 12, 2003·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Sep 17, 2009·Archives of Dermatological Research·Visalini Muthusamy, Terrence J Piva
Dec 5, 2012·Journal of Natural Medicines·Ippei HoribeYasuo Nagaoka
Feb 5, 2003·Biochemical Pharmacology·Eric Van Den NesteFrançoise Bontemps
Jul 23, 2003·Cellular Signalling·Dong-Seok KimKyoung-Chan Park
Nov 19, 2011·Photochemistry and Photobiology·Hideki NishiuraMasami Watanabe
Sep 8, 2010·Pigment Cell & Melanoma Research·Nanao HorikeHiroshi Takemori
Jul 10, 2007·Bioscience, Biotechnology, and Biochemistry·Hoon-Seok YoonSe-Jae Kim
Jul 16, 2002·Environmental Health Perspectives·Lisa A CarterLisa A Bonner
Aug 30, 2003·Photochemistry and Photobiology·Rozen Le PanseBernard Coulomb
Feb 9, 2012·International Journal of Molecular Sciences·César López-CamarilloLaurence A Marchat
Mar 20, 2009·International Journal of Radiation Biology·Andrew J RidleySarah L Allinson
Sep 28, 2010·Journal of Dermatological Science·Mi Yoon KimTae-Jin Yoon
Mar 5, 2016·Scientific Reports·Anser AliPankaj Attri
Jan 29, 2005·The Journal of Investigative Dermatology·Jongsung LeeDeokhoon Park
Oct 14, 2014·The Journal of Investigative Dermatology·Jonathan A HardmanRalf Paus
Apr 29, 2011·The Journal of Investigative Dermatology·Eun-Jung LeeTae-Yoon Kim
Aug 14, 2003·Photodermatology, Photoimmunology & Photomedicine·M Badawy Abdel-NaserJürgen Eberle
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Keiran S M Smalley
Sep 9, 2011·The Journal of Pharmacy and Pharmacology·Young-Ok SonJeong-Chae Lee
Dec 21, 2010·Experimental Dermatology·Ju Eun LeeDong-Seok Kim
Jun 20, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hwayong ParkJin Yeul Ma
Mar 19, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyong-Suk JinByung Woo Kim
Apr 27, 2005·Chemistry & Biology·Gus R Rosania
Jan 30, 2003·Science's STKE : Signal Transduction Knowledge Environment·Ann M Bode, Zigang Dong
Apr 7, 2017·Journal of Cellular and Molecular Medicine·Ding'an ZhouQinghe Xing
Aug 2, 2003·Nature Reviews. Cancer·Lynda Chin
Jun 28, 2016·Biomedical Reports·Jing-Hua WangNing Zhang
Jun 22, 2017·Experimental Dermatology·Suman K SinghDesmond J Tobin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.