Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia

Glia
Kaoru Nasu-TadaK Inoue

Abstract

We have recently demonstrated that the P2X4 receptor, an ATP-gated cation channel, in spinal microglia is a key molecule that mediates the mechanical allodynia induced by peripheral nerve injury. Although microglial P2X4 receptor expression is increased after peripheral nerve injury, the molecular mechanism(s) underlying its upregulation remains largely unknown. Fibronectin is a member of the extracellular matrix molecules and is actively produced in response to injury and diseases in the CNS. Here, we describe the influence of fibronectin on P2X4 receptor expression in microglia and the upregulation of fibronectin after peripheral nerve injury. Microglia that were cultured on fibronectin-coated dishes showed a marked increase in P2X4 receptor expression, both at the mRNA and protein levels, as compared to those cultured on control dishes. Fibronectin also enhanced the microglial Ca2+ responses mediated by P2X4 receptors. Moreover, Western blot examination of the spinal cord from a rat with spinal nerve injury indicated that fibronectin was upregulated on the ipsilateral side. Interestingly, intrathecal injection of ATP-stimulated microglia to the rat lumber spinal cord revealed that microglia cultured on fibronectin-coated dis...Continue Reading

References

Oct 1, 1992·The American Journal of Physiology·L V Thompson, R H Fitts
Jan 1, 1992·Acta Neuropathologica·M FarooqueY Olsson
Apr 1, 1992·Journal of Neurochemistry·K NakajimaS Kohsaka
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Raghow
Aug 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K A Venstrom, L F Reichardt
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·F SotoW Stühmer
Feb 1, 1996·Trends in Neurosciences·L S Jones
May 26, 1999·Journal of Neuroscience Research·M G VogelezangC ffrench-Constant
Feb 24, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·S NagD J Stewart
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Fang L ZhangFrederick Monsma
Oct 16, 2002·Glia·Kazuhide Inoue
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard Milner, Iain L Campbell
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nima NourhaghighiSukriti Nag
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Veronica J TomJerry Silver
Jan 26, 2005·Trends in Neurosciences·Makoto TsudaMichael W Salter

❮ Previous
Next ❯

Citations

Jan 10, 2012·Purinergic Signalling·Emika ToyomitsuKazuhide Inoue
Apr 25, 2012·Purinergic Signalling·Tuan Trang, Michael W Salter
Sep 3, 2013·Neuroscience Letters·Simon Beggs, Michael W Salter
Jul 28, 2012·Nature Neuroscience·Simon BeggsMichael W Salter
Jul 2, 2008·Nature Reviews. Drug Discovery·Geoffrey Burnstock
Dec 20, 2008·Nature Reviews. Neuroscience·Erin D Milligan, Linda R Watkins
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Makoto TsudaKazuhide Inoue
Mar 7, 2012·The Journal of Biological Chemistry·Estelle Toulme, Baljit S Khakh
Mar 17, 2010·The Journal of General Physiology·Estelle ToulmeBaljit S Khakh
Oct 4, 2013·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuhide Inoue
May 18, 2007·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Makoto Tsuda
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tuan TrangMichael W Salter
Nov 28, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Katherine A Mifflin, Bradley J Kerr
May 14, 2014·Nature Communications·Takahiro MasudaKazuhide Inoue
Oct 4, 2013·Neural Plasticity·Francesco Ferrini, Yves De Koninck
Oct 3, 2014·BioMed Research International·Giulia Magni, Stefania Ceruti
Feb 5, 2016·ACS Chemical Neuroscience·Takahiro Masuda, Marco Prinz
Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes
Sep 8, 2010·Current Opinion in Neurobiology·Simon Beggs, Michael W Salter
Nov 26, 2009·Brain Research Reviews·Makoto TsudaKazuhide Inoue
Mar 24, 2009·Glia·Kazuhide Inoue, Makoto Tsuda
Aug 19, 2007·Journal of Neurochemistry·Kazuhide InoueMakoto Tsuda
Apr 11, 2008·Journal of Cellular and Molecular Medicine·Zhi-Yuan ZhangHermann J Schluesener
Jun 29, 2012·Glia·Makoto TsudaKazuhide Inoue
Sep 16, 2006·Biochemical and Biophysical Research Communications·Liang-Hao GuoHermann J Schluesener
Nov 1, 2011·Current Opinion in Pharmacology·Makoto TsudaKazuhide Inoue
Nov 26, 2011·Experimental Neurology·Tuan TrangMichael W Salter
Feb 11, 2015·Experimental Parasitology·Ling-Yuh ShyuShih-Chan Lai
Sep 29, 2011·Experimental Neurology·Kazuhide Inoue, Makoto Tsuda
Nov 18, 2010·Journal of Pharmacological Sciences·Takayuki Nakagawa, Shuji Kaneko
Jan 23, 2013·Journal of Pharmacological Sciences·Makoto TsudaKazuhide Inoue
May 2, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kazuhide Inoue
Apr 18, 2017·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Kazuhide Inoue
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.