PMID: 9534885Apr 16, 1998Paper

Possible involvement of interleukin-1 in the pathogenesis of dermatofibroma

Acta Dermato-venereologica
T YamamotoK Nishioka

Abstract

Dermatofibroma (DF) is histologically characterized by proliferation of fibroblasts in the dermis. Multiple DFs occasionally develop in patients with autoimmune disorders under immunosuppressive therapy; however, the pathogenesis of DF is still unclear. To elucidate immunological involvement in the mechanism of the fibrosis in DF, we studied the role of interleukin-1 (IL-1), which has a number of biological functions, including proliferation and collagen production of fibroblasts, on DF-derived fibroblasts. 3H-thymidine incorporation was used to examine the effects of Il-1 alpha and IL-1 beta in 4 cultured fibroblast strains derived from DF and 5 fibroblast strains from normal skin. Expression of mRNA of IL-1 was also analyzed by reverse transcriptase polymerase chain reaction (RT-PCR). Basal 3H-TdR incorporation without stimulant of DF-derived fibroblasts showed a significantly greater growth activity than normal skin-derived fibroblasts (2, 632 +/- 525 vs. 762 +/- 144 dpm, p < 0.01). Both IL-1 alpha and IL-1 beta showed a stronger growth-stimulatory activity on DF-derived fibroblasts in a dose-dependent manner than normal fibroblasts, and the percent 3H-TdR uptake of DF was 1.4-fold (IL-1 alpha; 1,000 U/ml) and 1.3-fold (IL-1...Continue Reading

Citations

May 16, 2000·The British Journal of Dermatology·S E ChangJ K Koh
Nov 24, 2007·Actas dermo-sifiliográficas·C García-MillánP Jaén
Sep 27, 2005·The British Journal of Dermatology·H-W LeeJ-K Koh
Jan 30, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·T Yamamoto
Feb 24, 2005·Clinical and Experimental Dermatology·I ChanJ E Mellerio
Jun 20, 2012·Immunology and Cell Biology·Mithila BuruteSanjeev Galande
Mar 20, 2015·Cancer Science·Eishi AshiharaTaira Maekawa

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