PMID: 8950290Jan 1, 1996Paper

Possible involvement of mu 2-opioid receptor-mediated mechanisms in morphine-induced enhancement of the pentobarbital-induced loss of the righting reflex in the mouse

Life Sciences
J KameiH Nagase

Abstract

The effects of pretreatment with selective mu-, delta- and kappa-opioid receptor antagonists on the enhancement of the pentobarbital-induced loss of the righting reflex by morphine were examined in mice. Mice injected with pentobarbital (50 mg/kg, i.p.) showed an increased duration for the loss of the righting reflex after administration of morphine. This enhancement of the pentobarbital-induced loss of the righting reflex produced by morphine (10 mg/kg, s.c.) was significantly antagonized by pretreatment with beta-funaltrexamine, a selective mu-opioid receptor antagonist, but not by pretreatment with naloxonazine, a selective mu 1-opioid receptor antagonist. Furthermore, neither naltrindole, a selective delta-opioid receptor antagonist, nor nor-binaltorphimine, a selective kappa-opioid receptor antagonist, had a significant effect on the enhancement of the pentobarbital-induced loss of the righting reflex by morphine. These results suggest that mu 2-, rather than mu 1-, delta- and kappa-, opioid receptor-mediated mechanisms are involved in the morphine-induced enhancement of the pentobarbital-induced loss of the righting reflex.

References

Oct 1, 1986·Neuropharmacology·E C CrichlowR D Crawford
Oct 1, 1985·Pharmacology, Biochemistry, and Behavior·S FatheraziA Horita
Jan 1, 1974·Pharmacology·B D Cherksey, N Altszuler
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·R A Howd, G T Pryor
Jan 1, 1964·Biochemical Pharmacology·W F BOUSQUETT S MIYA

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Citations

Jun 1, 2001·Toxicon : Official Journal of the International Society on Toxinology·P BrigatteY Cury
Jun 29, 2012·The Journal of Pharmacology and Experimental Therapeutics·Sarah M BrownEvan D Kharasch
Jan 17, 2009·Journal of Ethnopharmacology·Ana Carla C S CarvalhoRosilene M Marçal

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